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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEfficacy Of A Whey Protein Concentrate On The Inhibition Of Stomach Ulcerative Lesions Caused By Ethanol Ingestionpt_BR
dc.contributor.authorRosaneli C.F.pt_BR
dc.contributor.authorBighetti A.E.pt_BR
dc.contributor.authorAntonio M.A.pt_BR
dc.contributor.authorCarvalho J.E.pt_BR
dc.contributor.authorSgarbieri V.C.pt_BR
unicamp.authorBighetti, A.E., Ctro. Pluridiscip. de Pesq. Quimicas, Biologicas e Agricolas (CPQBA), Universidade Estadual de Campinas, n 999, Vila Betel - 13.140, Campinas, SP, Brazil, Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazilpt_BR
unicamp.authorAntonio, M.A., Ctro. Pluridiscip. de Pesq. Quimicas, Biologicas e Agricolas (CPQBA), Universidade Estadual de Campinas, n 999, Vila Betel - 13.140, Campinas, SP, Brazil, Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazilpt_BR
unicamp.authorCarvalho, J.E., Ctro. Pluridiscip. de Pesq. Quimicas, Biologicas e Agricolas (CPQBA), Universidade Estadual de Campinas, n 999, Vila Betel - 13.140, Campinas, SP, Brazil, Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brazilpt_BR
unicamp.author.externalRosaneli, C.F., Instituto de Tecnologia de Alimentos, Av. Brasil, 2880, CEP 13081-001, Campinas, SP, Brazilpt
unicamp.author.externalSgarbieri, V.C., Instituto de Tecnologia de Alimentos, Av. Brasil, 2880, CEP 13081-001, Campinas, SP, Brazilpt
dc.description.abstractThe purpose of this research was to test the ability of a whey protein concentrate (WPC) to inhibit gastric mucosal ulcerative lesions caused by oral administration to rats of absolute ethanol. Acute administration (single doses) of WPC resulted in 41% inhibition of the ulcerative lesion index (ULI), and 73% inhibition was obtained with repetitive doses. In a 10-days subchronic treatment study, the inhibition was 64%, all relative to a saline treatment (negative control). Alkylation of sulfhydryl compounds by subcutaneous injection of N-ethylmaleimide essentially eliminated the WPC protection. Treating the rats with an intraperitoneal injection of butathionine sulfoximine, which inhibits glutathione synthesis, reduced WPC protection to 35% and 52% for single and double doses, respectively. Taken as a whole, the results indicate that WPC does protect gastric mucosa from ethanol damage and that the protection depends on sulfhydryl compounds present in the WPC, including its capacity to stimulate glutathione synthesis.en
dc.relation.ispartofJournal of Medicinal Foodpt_BR
dc.date.issued2002pt_BR
dc.identifier.citationJournal Of Medicinal Food. , v. 5, n. 4, p. 221 - 228, 2002.pt_BR
dc.language.isoenpt_BR
dc.description.volume5pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage221pt_BR
dc.description.lastpage228pt_BR
dc.rightsfechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn1096620Xpt_BR
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-0036933993&partnerID=40&md5=ceeadcaa65866a093fbd486c7f7ffd84pt_BR
dc.date.available2015-06-30T16:44:47Z
dc.date.available2015-11-26T15:37:11Z-
dc.date.accessioned2015-06-30T16:44:47Z
dc.date.accessioned2015-11-26T15:37:11Z-
dc.description.provenanceMade available in DSpace on 2015-06-30T16:44:47Z (GMT). No. of bitstreams: 1 2-s2.0-0036933993.pdf: 146844 bytes, checksum: c986f8707f1b33c54f59a91c49405231 (MD5) Previous issue date: 2002en
dc.description.provenanceMade available in DSpace on 2015-11-26T15:37:11Z (GMT). No. of bitstreams: 2 2-s2.0-0036933993.pdf: 146844 bytes, checksum: c986f8707f1b33c54f59a91c49405231 (MD5) 2-s2.0-0036933993.pdf.txt: 25462 bytes, checksum: 573aedbf854b582a6469727fe1d1c33f (MD5) Previous issue date: 2002en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/101890
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/101890-
dc.identifier.idScopus2-s2.0-0036933993pt_BR
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