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Type: Artigo de periódico
Title: Evaluation Of The Antiulcerogenic Activity Of Violacein And Its Modulation By The Inclusion Complexation With β-cyclodextrin
Author: Duran N.
Justo G.Z.
Melo P.S.
De Azevedo M.B.M.
Souza Brito A.R.M.
Almeida A.B.A.
Haun M.
Abstract: The effects of β-cyclodextrin (βCD) inclusion complexation on the ability of violacein to prevent gastric ulceration in mice were studied. Violacein-βCD inclusion complexes were prepared in 1:1 and 1:2 molar ratios and analysed by differential scanning calorimetry and powder X-ray diffractometry. Violacein previously administered orally at 10 mg/kg significantly reduced indomethacin-induced gastric lesions, as well as 100 mg/kg of cimetidine (positive control). However, βCD complexation in both molar ratios significantly potentiated the protective action of violacein. In the HCl-ethanol-induced gastric ulcer model, violacein and the 1:2 inclusion complex (10 mg/kg, p.o.) inhibited gastric damage by almost 85%, whereas a 63% reduction was observed for the positive control, lansoprazole, at 30 mg/kg. In contrast, treatment with the 1:1 inclusion complex resulted in almost total disappearance of the antiulcer activity in this model. No significant changes in stress-induced gastric injury were found. In addition, the 1:2 inclusion complex improved the antilipoperoxidant activity of violacein in rat liver cells exposed to t-butyl hydroperoxide, whereas the 1:1 complex was less active than violacein. In summary, the 1:2 βCD inclusion complex has gastroprotective properties similar to or higher than that of violacein. An increase in mucosal defensive mechanisms and protection against peroxidative damage might be involved.
Citation: Canadian Journal Of Physiology And Pharmacology. , v. 81, n. 4, p. 387 - 396, 2003.
Rights: fechado
Identifier DOI: 10.1139/y03-033
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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