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Type: Artigo de periódico
Title: Antiproliferative Activity Of Extracts And Fractions From Virola Sebifera Aubl. Leaves (myristicaceae) [atividade Antiproliferativa Dos Extratos E Da Fração Orgânica Obtidos Das Folhas De Virola Sebifera Aubl. (myristicaceae)]
Author: Denny C.
Zacharias M.E.
Kohn L.K.
Foglio M.A.
De Carvalho J.E.
Abstract: Barks of Virola sebifera (Myristicaceae) used by Amazonian Indian communities in hallucinogenic snuff preparations have yielded dimethyltryptamine and derivatives. Considering the importance of the alkaloids isolated from plants for the development of chemotherapy, and the presence of these compounds in several Virola species, the scope of this work was to evaluate the antiproliferative activity of the extracts and the organic fraction from Virola sebifera leaves. The crude dichloromethane extract was the most active with selectivity for lung line (NCI-460) - IC 50: 4.46 μg/mL, as well as the organic fraction (OF) - IC 50: 6.91 μg/mL. The observed activity could probably be attributed to alkaloids or nitrogen compounds that were evidenced by the Dragendorff reagent. However, the future purification of OF will be necessary to prove the presence of alkaloids and their role in the antiproliferative activity in human cells as well as isolating and identifying these compounds.
Citation: Brazilian Journal Of Pharmacognosy. , v. 17, n. 4, p. 598 - 603, 2007.
Rights: aberto
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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