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Type: Artigo de periódico
Title: Synthesis And Biological Activity Of 6-formyl-oxamniquine Derivative [síntese E Atividade Biológica Do Derivado 6-formil-oxamniquina]
Author: De Almeida A.E.
De Souza A.L.R.
Allegretti S.M.
Frezza T.F.
Pinto M.C.
Ferreira A.G.
Man C.C.
Abstract: Schistosomiasis, an important disease in Brazil, is caused by a trematode of the genus Schistosoma, reaching millions of person in one of the most endemic region of this disease in the whole globe. The main goal of this work was to syntetize the 6-formyl- oxamniquine derivative and evaluate its biological activity. The 6-formyl-oxamniquine derivative was obtained by the oxidation of oxamniquine with MnO 2, applying CH 2Cl 2 as solvent at room temperature for 24 hours. The obtaintion of 6-formyl-oxamniquine derivative compound was confirmed by IR spectroscopy and 13C NMR and 1H NMR, presenting similar activity when compared to the commercial oxamniquine (Mansil®).
Citation: Revista Brasileira De Ciencias Farmaceuticas/brazilian Journal Of Pharmaceutical Sciences. , v. 44, n. 4, p. 749 - 754, 2008.
Rights: fechado
Identifier DOI: 10.1590/S1516-93322008000400022
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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