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Type: Artigo de periódico
Title: Inflammatory Activity Of Pelvic Ileal Pouches Mucosa In Asymptomatic Patients [processo Inflamatório Em Mucosa De Reservatórios Ileais De Doentes Assintomáticos]
Author: Leal R.F.
Ayrizono M. de L.S.
Milanski M.
Fagundes J.J.
Coope A.
Angelo S.N.
Velloso L.A.
Coy C.S.R.
Abstract: Pouchitis after total retocolectomy is the most common complication in ulcerative colitis (UC). The immunological mechanisms involved in the genesis of pouchitis are unclear. Purpose: To evaluate STAT-1 activation and IFN-a expression in normal ileal pouch mucosa. Methods: Eighteen asymptomatic patients submitted to total retocolectomy and J pouch, were evaluated, being nine with UC and nine with FAP. The activation of STAT-1 and expressions of the cytokine were determined by immunoblot of total protein extracts from pouch mucosal biopsies. Results: STAT-1 activation was increased in UC, when compared to FAP and controls. Higher levels of IFN-γ expression were observed in UC when compared to control group, but was similar to FAP. Conclusions: These findings could explain a higher susceptibility to this inflammatory complication in UC when compared to FAP, which may be similar to UC disease.
Citation: Revista Brasileira De Coloproctologia. , v. 28, n. 4, p. 443 - 448, 2008.
Rights: aberto
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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