Please use this identifier to cite or link to this item:
|Type:||Artigo de periódico|
|Title:||Anti-inflammatory Properties Of A Heparin-like Glycosaminoglycan With Reduced Anti-coagulant Activity Isolated From A Marine Shrimp|
|Abstract:||The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug. © 2008 Elsevier Ltd. All rights reserved.|
|Citation:||Bioorganic And Medicinal Chemistry. , v. 16, n. 21, p. 9588 - 9595, 2008.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.