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Type: Artigo de periódico
Title: Anti-inflammatory Properties Of A Heparin-like Glycosaminoglycan With Reduced Anti-coagulant Activity Isolated From A Marine Shrimp
Author: Brito A.S.
Arimateia D.S.
Souza L.R.
Lima M.A.
Santos V.O.
Medeiros V.P.
Ferreira P.A.
Silva R.A.
Ferreira C.V.
Justo G.Z.
Leite E.L.
Andrade G.P.V.
Oliveira F.W.
Nader H.B.
Chavante S.F.
Abstract: The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p < 0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug. © 2008 Elsevier Ltd. All rights reserved.
Citation: Bioorganic And Medicinal Chemistry. , v. 16, n. 21, p. 9588 - 9595, 2008.
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2008.09.020
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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