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Type: Artigo de periódico
Title: Rat Skin Wound Healing Induced By Alternagin-c, A Disintegrin-like, Cys-rich Protein From Bothrops Alternatus Venom
Author: Sant'Ana E.M.C.
Gouvea C.M.C.P.
Durigan J.L.Q.
Cominetti M.R.
Pimentel E.R.
Selistre-de-Araujo H.S.
Abstract: Alternagin-C (ALT-C) is a disintegrin-like, Cys-rich protein isolated from Bothrops alternatus snake venom, which has been shown to induce in vivo angiogenesis. Therefore, this protein could be interesting as a new approach for tissue regeneration studies. Here the effects of ALT-C on fibroblasts and inflammatory cells, collagen type III and type I and TGF-α expression in a rat wounded skin model were studied. Thirty-five male Wistar rats (weight 270 ± 20 g) were divided into seven groups with five animals in each of the following groups: a control group which wounded animals received treatment with natrozol® gel only; ALT-C10, ALT-C60 and ALT-C100 groups of wounded animals that were treated with the same amount of gel containing 10, 60 and 100 ng of ALT-C, respectively. Animals were treated once a day with 20 μl of gel associated or not with ALT-C for 1, 3, 5 or 7 days. ALT-C treatment increased the fibroblast density, collagen deposition and accelerated the inflammatory process, mostly in the ALT-C60 group. These results indicate that ALT-C improves wound repair process in rat skin. Thus, ALT-C could be a candidate to the development of a novel therapeutic strategy for wounded skin repair. © 2011 The Authors. © 2011 Blackwell Publishing Ltd and Inc.
Citation: International Wound Journal. , v. 8, n. 3, p. 245 - 252, 2011.
Rights: fechado
Identifier DOI: 10.1111/j.1742-481X.2011.00776.x
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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