Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Abnormal Production Of Transforming Growth Factor Beta And Interferon Gamma By Peripheral Blood Cells Of Patients With Multidrug-resistant Pulmonary Tuberculosis In Brazil.
Author: Castro, Analia Z
Diaz-Bardalez, Blanca M
Oliveira, Elaine C
Garcia, Reinaldo C
Afiune, Jorge Barros
Paschoal, Ilma A
Santos, Leonilda M B
Abstract: The aim of the present study was to determine the immune response profile that differentiates patients with newly diagnosed (non-treated) pulmonary tuberculosis from multidrug-resistant (MDR) ones, as well as from healthy, tuberculin positive individuals. Lymphocytes proliferative response to non-specific mitogen (PHA) and PPD were evaluated by 3H thymidine incorporation and cytokines were quantified using an ELISA assay. Patients with active disease showed a diminished proliferative response to PHA and PPD, while multidrug-resistant patients showed a diminished proliferative response to PHA, but a normal response to PPD. The cytokine production of newly diagnosed patients was characterized by a diminished production of IFNgamma and normal production of transforming growth factor (TGFbeta), while MDR patients revealed a normal production of IFNgamma accompanied by an increase in TGFbeta. The production of significant amounts of TGFbeta in MDR patients leads to a poor immune response and may contribute to the resistance of tuberculosis patients to drugs.
Subject: Adult
Case-control Studies
Drug Resistance, Multiple
Enzyme-linked Immunosorbent Assay
Immunity, Cellular
Leukocytes, Mononuclear
Lymphocyte Activation
Middle Aged
Mycobacterium Tuberculosis
Transforming Growth Factor Beta
Tuberculosis, Pulmonary
Citation: The Journal Of Infection. v. 51, n. 4, p. 318-24, 2005-Nov.
Rights: fechado
Identifier DOI: 10.1016/j.jinf.2004.08.035
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_16291285.pdf133.26 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.