Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/24167
Type: Artigo de periódico
Title: Alternative mitochondrial functions in cell physiopathology: beyond ATP production
Author: Kowaltowski, A.J.
Abstract: It is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology.
Subject: mitochondrial permeability transition
uncoupling proteins
alternative oxidase
cardioprotection
free radicals
aging
Editor: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 33, n. 2, p. 241-250, 2000.
Rights: aberto
Identifier DOI: 10.1590/S0100-879X2000000200014
Address: http://dx.doi.org/10.1590/S0100-879X2000000200014
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200014
Date Issue: 1-Feb-2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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