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Type: Artigo de periódico
Title: Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC
Author: Bayeux, M.C.
Fernandes, A.T.
Foglio, M.A.
Carvalho, J.E.
Abstract: The species Cordia curassavica (Boraginaceae), known popularly as erva baleeira, is used in folk medicine for the treatment of several inflammatory processes and as a healing agent. The objective of the present study was to evaluate the antiedematogenic activity of crude dichloromethane extracts of Cordia curassavica and of the artemetin-enriched fraction. The crude extract and artemetin fraction were tested in the model of carrageenin-induced paw edema in male Swiss mice (25-30 g). The crude dichloromethane extract (300 and 1000 mg/kg, po, N = 6) showed significant antiedematogenic activity, reducing the edema by 42, 57 and 45% and 46, 62 and 69%, 3, 4 and 5 h after carrageenin administration, respectively. Indomethacin (10 mg/kg, po, N = 6) reduced the edema by 45 and 48%, after 4 and 5 h, but the artemetin-enriched fraction (30, 100 and 300 mg/kg, po, N = 6) had no activity. The dichloromethane extract (300 and 1000 mg/kg, po, N = 6) also showed antinociceptive activity by reducing acetic acid-induced writhing in mice from 37.1 ± 2.28 (control) to 17.3 ± 1.34 and 13.2 ± 1.44, respectively, but had no activity in the hot-plate test.
Subject: Cordia curassavica
Cordia verbenaceae
Medicinal plants
Editor: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 10, p. 1229-1232, 2002.
Rights: aberto
Identifier DOI: 10.1590/S0100-879X2002001000017
Date Issue: 1-Oct-2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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