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Type: Artigo de periódico
Title: Refractory And Resistant Hypertension: Characteristics And Differences Observed In A Specialized Clinic
Author: Modolo
Rodrigo; de Faria
Ana Paula; Sabbatini
Andrea Rodrigues; Barbaro
Natalia Ruggeri; Ritter
Alessandra M. V.; Moreno
Abstract: Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite the use of >= 3 anti-hypertensive drugs, or controlled requiring use of >= 4 drugs. Recently, a new definition for an extreme phenotype of RH (uncontrolled BP using at least five drugs) has emerged-the refractory hypertension (RfH). Although characteristics of RH are well established, little is known about this newly described subgroup. For this work, 116 subjects with RH were enrolled from a specialized clinic and divided into RH (n = 80) and RfH (n = 36). Subjects were submitted to echocardiography, 24-hour ambulatory BP measurement and biochemical analyses. Logistic regression analysis demonstrated that: (1) white coat effect (odds ratio [OR], 3.23; 95% confidence interval [CI], 1.12-9.27; P = .03), (2) black race (OR, 6.67; 95% CI, 1.99-16.16; P < .001), and (3) left ventricular mass index (OR, 1.02; 95% CI, 1.01-1.03; P = .04) were independent predictors of refractoriness. In conclusion, RfH and RH present different patient characteristics, and these phenotypic aspects can be useful for better understanding this harder-to-treat subgroup. 2015 American Society of Hypertension. All rights reserved.
Subject: High-blood-pressure
Country: NEW YORK
Citation: Refractory And Resistant Hypertension: Characteristics And Differences Observed In A Specialized Clinic. Elsevier Science Inc, v. 9, p. 397-402 MAY-2015.
Rights: embargo
Identifier DOI: 10.1016/j.jash.2015.03.005
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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