Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/244195
Type: Artigo
Title: Aberrant topological patterns of brain structural network in temporal lobe epilepsy
Author: Yasuda, Clarissa Lin
Chen, Zhang
Beltramini, Guilherme Coco
Coan, Ana Carolina
Morita, Marcia Elisabete
Kubota, Bruno
Bergo, Felipe
Beaulieu, Christian
Cendes, Fernando
Gross, Donald William
Abstract: ObjectiveAlthough altered large-scale brain network organization in patients with temporal lobe epilepsy (TLE) has been shown using morphologic measurements such as cortical thickness, these studies, have not included critical subcortical structures (such as hippocampus and amygdala) and have had relatively small sample sizes. Here, we investigated differences in topological organization of the brain volumetric networks between patients with right TLE (RTLE) and left TLE (LTLE) with unilateral hippocampal atrophy. MethodsWe performed a cross-sectional analysis of 86 LTLE patients, 70 RTLE patients, and 116 controls. RTLE and LTLE groups were balanced for gender (p = 0.64), seizure frequency (Mann-Whitney U test, p = 0.94), age (p = 0.39), age of seizure onset (p = 0.21), and duration of disease (p = 0.69). Brain networks were constructed by thresholding correlation matrices of volumes from 80 cortical/subcortical regions (parcellated with Freesurfer v5.3 ) that were then analyzed using graph theoretical approaches. ResultsWe identified reduced cortical/subcortical connectivity including bilateral hippocampus in both TLE groups, with the most significant interregional correlation increases occurring within the limbic system in LTLE and contralateral hemisphere in RTLE. Both TLE groups demonstrated less optimal topological organization, with decreased global efficiency and increased local efficiency and clustering coefficient. LTLE also displayed a more pronounced network disruption. Contrary to controls, hub nodes in both TLE groups were not distributed across whole brain, but rather found primarily in the paralimbic/limbic and temporal association cortices. Regions with increased centrality were concentrated in occipital lobes for LTLE and contralateral limbic/temporal areas for RTLE. SignificanceThese findings provide first evidence of altered topological organization of the whole brain volumetric network in TLE, with disruption of the coordinated patterns of cortical/subcortical morphology.
Objective: Although altered large-scale brain network organization in patients withtemporal lobe epilepsy (TLE) has been shown using morphologic measurements suchas cortical thickness, these studies, have not included critical subcortical structures(such as hippocampus and amygdala) and have had relatively small sample sizes. Here,we investigated differences in topological organization of the brain volumetric net-works between patients with right TLE (RTLE) and left TLE (LTLE) with unilateral hip-pocampal atrophy. Methods: We performed a cross-sectional analysis of 86 LTLE patients, 70 RTLEpatients, and 116 controls. RTLE and LTLE groups were balanced for gender(p=0.64), seizure frequency (Mann-WhitneyUtest, p=0.94), age (p=0.39), age ofseizure onset (p=0.21), and duration of disease (p=0.69). Brain networks were con-structed by thresholding correlation matrices of volumes from 80 cortical/subcorticalregions (parcellated with Freesurfer v5.3 https://surfer.nmr.mgh.harvard.edu/) thatwere then analyzed using graph theoretical approaches. Results: We identified reduced cortical/subcortical connectivity including bilateral hip-pocampus in both TLE groups, with the most significant interregional correlationincreases occurring within the limbic system in LTLE and contralateral hemisphere inRTLE. Both TLE groups demonstrated less optimal topological organization, withdecreased global efficiency and increased local efficiency and clustering coefficient.LTLE also displayed a more pronounced network disruption. Contrary to controls,hub nodes in both TLE groups were not distributed across whole brain, but ratherfound primarily in the paralimbic/limbic and temporal association cortices. Regionswith increased centrality were concentrated in occipital lobes for LTLE and contralat-eral limbic/temporal areas for RTLE.Significance:These findings provide first evidence of altered topological organizationof the whole brain volumetric network in TLE, with disruption of the coordinated pat-terns of cortical/subcortical morphology.
Subject: Epilepsia do lobo temporal mesial
Teoria dos grafos
Country: Estados Unidos
Editor: Wiley-Blackwell Publishing
Citation: Aberrant Topological Patterns Of Brain Structural Network In Temporal Lobe Epilepsy. Wiley-blackwell, v. 56, p. 1992-2002 DEC-2015.
Rights: fechado
Identifier DOI: 10.1111/epi.13225
Address: https://onlinelibrary.wiley.com/doi/full/10.1111/epi.13225
Date Issue: 2015
Appears in Collections:IFGW - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos
FT - Artigos e Outros Documentos

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