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|Type:||Artigo de Periódico|
|Title:||Coactivation Of Mu- And Kappa-opioid Receptors May Mediate The Protective Effect Of Testosterone On The Development Of Temporomandibular Joint Nociception In Male Rats|
|Abstract:||To investigate whether the protective effect of testosterone on the development of temporomandibular joint (TMJ) nociception in male rats is mediated by the activation of central opioid mechanisms. Methods: Experiments were performed on 156 male Wistar rats. A pharmacologic approach was used to assess the ability of opioid receptor antagonists infused into the dorsal portion of the brainstem and adjacent to the caudal component (subnucleus caudalis) of the spinal trigeminal nucleus to block the protective effect of testosterone in male rats. The TMJ injection of 0.5% formalin was used as a nociceptive stimulus. One-way or two-way ANOVA was used for data analyses. Results: The injection of 0.5% formalin into the TMJ induced a significant nociceptive behavior in gonadectomized male rats (P <.05), but not in naive, sham, and testosteronereplaced gonadectomized rats, confirming that testosterone prevents the development of TMJ nociception. The injection of either the nonselective opioid receptor antagonist naloxone (15 mu g) or the simultaneous injection of the mu-opioid receptor antagonist Cys2, Tyr3, Orn5, Pen7amide (CTOP, 30 mu g) and the kappa-opioid receptor antagonist Nor-Binaltorphimine (Nor-BNI, 90 mu g) significantly increased the 0.5% formalin-induced behavioral response in sham and testosteronereplaced gonadectomized rats (P <.05) but had no effect in gonadectomized rats. However, the injection of each selective opioid receptor antagonist alone or the simultaneous injection of mu- or kappa-and d-opioid receptor antagonists had no effect. Conclusion: These findings indicate that the protective effect of endogenous testosterone on the development of TMJ nociception in male rats is mediated by the activation of central opioid mechanisms. Furthermore, the coactivation of central mu- and kappa-opioid receptors is necessary for testosterone to protect male rats from developing TMJ nociception.|
|Editor:||QUINTESSENCE PUBLISHING CO INC|
|Citation:||Journal Of Oral & Facial Pain And Headache. QUINTESSENCE PUBLISHING CO INC, n. 30, n. 1, p. 61 - 67.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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