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Type: Artigo
Title: The Role Of Endogenous Opioid Peptides In The Antinociceptive Effect Of 15-deoxy(delta 12,14)-prostaglandin J(2) In The Temporomandibular Joint
Author: Macedo
C. G.; Napimoga
M. H.; Rocha-Neto
L. M.; Abdalla
H. B.; Clemente-Napimoga
J. T.
Abstract: We have previously demonstrated that peripheral administration of 15d-PGJ(2) in the Temporomandibular joint (TMJ) of rats can prevent nociceptor sensitization, mediated by peroxisome proliferator activated receptor-gamma (PPAR-gamma), and kappa- and delta- opioid receptors. However, the mechanism that underlies the signaling of PPAR-gamma (upon activation by 15d-PGJ(2)) to induce antinociception, and how the opioid receptors are activated via 15d-PGJ(2) are not fully understood. This study demonstrates that peripheral antinociceptive effect of 15d-PGJ(2) is mediated by PPAR-gamma expressed in the inflammatory cells of TMJ tissues. Once activated by 15d-PGJ(2), PPAR-gamma induces the release of beta-endorphin and dynorphin, which activates kappa- and delta-opioid receptors in primary sensory neurons to induce the antinociceptive effect. (C) 2016 Elsevier Ltd. All rights reserved.
Editor: Elsevier Sci Ltd
Citation: Prostaglandins, Leukotrienes And Essential Fatty Acids . Elsevier Sci Ltd, v. 110, p. 27 - 34, 2016.
Rights: fechado
Identifier DOI: 10.1016/j.plefa.2016.05.009
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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