Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326807
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremailjuliana.napimoga@fop.unicamp.brpt_BR
dc.typeArtigopt_BR
dc.titleThe Role Of Endogenous Opioid Peptides In The Antinociceptive Effect Of 15-deoxy(delta 12,14)-prostaglandin J(2) In The Temporomandibular Jointen
dc.contributor.authorMacedopt_BR
dc.contributor.authorC. G.; Napimogapt_BR
dc.contributor.authorM. H.; Rocha-Netopt_BR
dc.contributor.authorL. M.; Abdallapt_BR
dc.contributor.authorH. B.; Clemente-Napimogapt_BR
dc.contributor.authorJ. T.pt_BR
unicamp.authorClemente-Napimoga, J. T.] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Physiol Sci, Lab Orofacial Pain, Av Limeira 901, BR-13414903 Piracicaba, SP, Brazilpt_BR
unicamp.author.external[Macedo, C. G.pt_BR
unicamp.author.externalRocha-Neto, L. M.pt_BR
unicamp.author.externalAbdalla, H. B.pt_BR
unicamp.author.external[Napimoga, M. H.] Rio Leopoldo Mand Inst & Res Ctr, Lab Immunol & Mol Biol, Rua Jose Rocha Junqueira 13, BR-13045755 Campinas, SP, Brazilpt_BR
dc.description.abstractWe have previously demonstrated that peripheral administration of 15d-PGJ(2) in the Temporomandibular joint (TMJ) of rats can prevent nociceptor sensitization, mediated by peroxisome proliferator activated receptor-gamma (PPAR-gamma), and kappa- and delta- opioid receptors. However, the mechanism that underlies the signaling of PPAR-gamma (upon activation by 15d-PGJ(2)) to induce antinociception, and how the opioid receptors are activated via 15d-PGJ(2) are not fully understood. This study demonstrates that peripheral antinociceptive effect of 15d-PGJ(2) is mediated by PPAR-gamma expressed in the inflammatory cells of TMJ tissues. Once activated by 15d-PGJ(2), PPAR-gamma induces the release of beta-endorphin and dynorphin, which activates kappa- and delta-opioid receptors in primary sensory neurons to induce the antinociceptive effect. (C) 2016 Elsevier Ltd. All rights reserved.en
dc.relation.ispartofProstaglandins, Leukotrienes and Essential Fatty Acidspt_BR
dc.publisherElsevier Sci Ltdpt_BR
dc.publisherOxfordpt_BR
dc.date.issued2016pt_BR
dc.date.monthofcirculationjulpt_BR
dc.identifier.citationProstaglandins, Leukotrienes And Essential Fatty Acids . Elsevier Sci Ltd, v. 110, p. 27 - 34, 2016.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume110pt_BR
dc.description.firstpage27pt_BR
dc.description.lastpage34pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0952-3278pt_BR
dc.identifier.eissn1532-2823pt_BR
dc.identifier.wosidWOS:000378184900004pt_BR
dc.identifier.doi10.1016/j.plefa.2016.05.009pt_BR
dc.identifier.urlhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S095232781530065X?via%3Dihubpt_BR
dc.description.sponsorshipCNPq [483988/2012]pt_BR
dc.description.sponsorshipCAPES (PROEX) [1830-2010]pt_BR
dc.description.sponsorshipFAPESP [2011/00683-5]pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2017-11-13T13:12:07Z-
dc.date.accessioned2017-11-13T13:12:07Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:12:07Z (GMT). No. of bitstreams: 1 000378184900004.pdf: 881332 bytes, checksum: e2ddac0927b252ff4e74edc049c63506 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/326807-
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