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Type: Artigo
Title: Anti-ribosomal P Antibody: A Multicenter Study In Childhood-onset Systemic Lupus Erythematosus Patients
Author: Valoes
C. C. M.; Molinari
B. C.; Pitta
A. C. G.; Gormezano
N. W. S.; Farhat
S. C. L.; Kozu
K.; Sallum
A. M. E.; Appenzeller
S.; Sakamoto
A. P.; Terreri
M. T.; Pereira
R. M. R.; Magalhaes
C. S.; Ferreira
J. C. O. A.; Barbosa
C. M.; Gomes
F. H.; Bonfa
E.; Silva
C. A.
Abstract: Anti-ribosomal P protein (anti-P) autoantibodies are highly specific for systemic lupus erythematosus (SLE). However, the evaluation of this autoantibody in childhood-onset SLE (cSLE) populations has been limited to a few small series, hampering the interpretation of the clinical and laboratorial associations. Therefore, the objective of this multicenter cohort study was to evaluate demographic, clinical/laboratorial features, and disease damage score in cSLE patients with and without the presence of anti-P antibody. Methods: This was a retrospective multicenter study performed in 10 pediatric rheumatology services of Sao Paulo state, Brazil. Anti-P antibodies were measured by ELISA in 228 cSLE patients. Results: Anti-P antibodies were observed in 61/228 (27%) cSLE patients. Frequencies of cumulative lymphadenopathy (29% vs. 15%, p = 0.014), acute confusional state (13% vs. 5%, p = 0.041), mood disorder (18% vs. 8%, p = 0.041), autoimmune hemolytic anemia (34% vs. 15%, p = 0.001), as well as presence of anti-Sm (67% vs. 40%, p = 0.001), anti-RNP (39% vs. 21%, p = 0.012) and anti-Ro/SSA antibodies (43% vs. 25%, p = 0.016) were significantly higher in cSLE patients with anti-P antibodies compared to those without these autoantibodies. A multiple regression model revealed that anti-P antibodies were associated with autoimmune hemolytic anemia (odds ratio (OR) = 2.758, 95% confidence interval (CI): 1.304-5.833, p = 0.008) and anti-Sm antibody (OR = 2.719, 95% CI: 1.365-5.418, p = 0.004). The SLICC/ACR damage index was comparable in patients with and without anti-P antibodies (p = 0.780). Conclusions: The novel association of anti-P antibodies and autoimmune hemolytic anemia was evidenced in cSLE patients and further studies are necessary to determine if anti-P titers may vary with this hematological manifestation.
Subject: Systemic Lupus Erythematosus
Anti-ribosomal P Protein Antibodies
Neuropsychiatric Lupus
Autoimmune Hemolytic Anemia
Editor: Sage Publications LTD
Citation: Lupus. Sage Publications Ltd, v. 26, p. 484 - 489, 2017.
Rights: fechado
Identifier DOI: 10.1177/0961203316676386
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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