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Type: Artigo
Title: Association Of Tnf Polymorphisms With Jak2 (v617f) Myeloproliferative Neoplasms In Brazilian Patients
Author: Macedo
Luciana Conci; Quintero
Fernanda de Cesare; Pagliari-E-Silva
Sara; Barbosa Pagnano
Katia Borgia; Rodrigues
Camila; de Alencar
Josiane Bazzo; Sell
Ana Maria; Laguila Visentainer
Jeane Eliete
Abstract: The classical chromosome Philadelphia-negative myeloproliferative neoplasms (MPNs) are a group of disorders that share clinical, hematological, and histological features. Proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) are elevated in patients with MPN. The aim of this study was to verify the association between the polymorphisms of TNF gene (-308G/A and-238 G/A) in BCR-ABL-negative MPN in our population. Blood samples obtained from MPN patients were genotyped for the JAK2V617F mutation and both TNF polymorphisms using PCR-RFLP. Thirty three (26.8%) patients with polycythemia vera (PV), 35 (28.7%) essential thrombocythemia (ET), 22 (17.7%) primary myelofibrosis (PMF), and 33 (26.8%) with unclassifiable MPN (MPNu) were included in the study. The JAK2 V617F mutation was detected in 94 (76.42%) patients. Were observed a significant increase on the frequency of the TNF-238 GA genotype in MPN patients compared to controls (OR = 221, 95% Cl = 1.02-4.80, P < 0.04). The distribution of the genotypes and allelic frequencies of TNF-308 was significantly different among the MPNs, JAK2V617F positive, PV and PMF, and controls. Our data has demonstrated that the polymorphisms on TNF-238 GA, TNF-308 GA were associated to MPN development in this population, triggered by JAK2 V617F mutation. (C) 2015 Published by Elsevier Inc.
Subject: Myeloproliferative Disorders
Editor: Academic Press Inc Elsevier Science
San Diego
Citation: Blood Cells, Molecules, And Diseases. Academic Press Inc Elsevier Science, v. 57, p. 54 - 57, 2016.
Rights: fechado
Identifier DOI: 10.1016/j.bcmd.2015.12.005
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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