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Type: Artigo
Title: Deregulation Of Soluble Adhesion Molecules In Resistant Hypertension And Its Role In Cardiovascular Remodeling
Author: de Faria
Ana Paula; Versuti Ritter
Alessandra Mileni; Sabbatini
Andrea Rodrigues; Correa
Nathalia Batista; Brunelli
Veridiana; Modolo
Rodrigo; Moreno
Abstract: Resistant hypertension (RHTN) and target organ damage are linked to increased inflammatory biomarkers, which may regulate adhesion molecules, such as intracellular adhesion molecule-1 (ICAM-1); vascular cell adhesion molecule-1 (VCAM-1); and the platelet (P-selectin) and endothelial (E-selectin) selectins. We investigated a previously unknown relationship between soluble P-selectin (sP-selectin), E-selectin (sE-selectin), ICAM-1 (sICAM-1) and VCAM-1 (sVCAM-1) with RHTN and target organ damage. Methods and Results: We included 110 subjects diagnosed for true RHTN and 112 mild-moderate hypertensive (HTN) patients. Blood pressure parameters, pulse wave velocity and left ventricular mass index (LVMI) were measured. Adhesion molecules were measured on ELISA. Both sP-selectin and sE-selectin were increased; in contrast, sICAM-1 was reduced in RHTN compared with HTN patients, while similar sVCAM-1 was noted in the groups. sP-selectin and sVCAM-1 were elevated in the presence of arterial stiffness (sP-selectin: 104 +/- 47 vs. 89 +/- 45 ng/ml, P<0.05; sVCAM-1: 1,189 +/- 411 vs. 1,060 +/- 412 ng/ml, P<0.05) and cardiac hypertrophy (sP-selectin: 105 +/- 51 vs. 88 +/- 43 ng/ml, P<0.05; sVCAM-1: 1,170 +/- 433 vs. 1,040 +/- 383 ng/ml, P<0.05) in all HTN patients. sP-selectin was associated with target organ damage after adjustment for age and BP. Apart from potential confounders, sE-selectin was a significant indicator of RHTN. Conclusions: The adhesion molecule sP-selectin plays a role in cardiovascular damage, and sE-selectin in resistance to antihypertensive therapy.
Subject: Adhesion Molecule
Arterial Stiffness
Cardiac Hypertrophy
Resistant Hypertension
Editor: Japanese Circulation Soc
Citation: Circulation Journal. Japanese Circulation Soc, v. 80, p. 1196 - 1201, 2016.
Rights: fechado
Identifier DOI: 10.1253/circj.CJ-16-0058
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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