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Type: Artigo
Title: Increased Circulating Tissue Inhibitor Of Metalloproteinase-2 Is Associated With Resistant Hypertension
Author: Sabbatini
Andrea R.; Barbaro
Natalia R.; de Faria
Ana Paula; Modolo
Rodrigo; Ritter
Alessandra Mileni V.; Pinho
Claudio; Amorim
Rivadavio Fernandes Batista; Fontana
Vanessa; Moreno
Abstract: Resistant hypertension (RH) is associated with organ damage and cardiovascular risk. Evidence suggests the involvement of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in hypertension and in cardiovascular remodeling. The aim of this study was to assess the levels of MMP-2 and TIMP-2 in RH and its relation with organ damage, including arterial stiffness and cardiac hypertrophy. MMP-2 and TIMP-2 levels were compared among 19 patients with normotension (NT), 116 with nonresistant hypertension (HTN) and 116 patients with resistant HTN (RH). MMP-2 levels showed no differences among NT, HTN, and RH groups, while TIMP-2 levels were higher in RH compared with HTN and NT groups (90.0 [76.1-107.3] vs 70.1 [57.7-88.3] vs 54.7 [40.9-58.1] ng/mL, P<.01), respectively. MMP-2/TIMP-2 ratio was reduced in the RH group compared with the HTN and NT groups (2.7 [1.9-3.4] vs 3.3 [2.6-4.2] vs 4.9 [4.5-5.3], P<.01), respectively. No associations were found between MMP-2 levels, TIMP-2, and MMP-2/TIMP-2 ratio with cardiac hypertrophy and arterial stiffness in the RH and HTN groups. Finally, in a regression analysis, reduced MMP-2/TIMP-2 ratio and increased TIMP-2 levels were independently associated with RH. The present findings provide evidence that TIMP-2 is associated with RH and might be a possible biomarker for screening RH patients. (C) 2016 Wiley Periodicals, Inc.
Editor: Wiley-Blackwell
Citation: Journal Of Clinical Hypertension. Wiley-blackwell, v. 18, p. 969 - 975, 2016.
Rights: fechado
Identifier DOI: 10.1111/jch.12865
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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