Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328339
Type: Artigo
Title: Anti-inflammatory And Anti-biofilm Properties Of Ent-nemorosone From Brazilian Geopropolis
Anti-inflammatory and anti-biofilm properties of ent-nemorosone from brazilian geopropolis
Author: da Cunha, Marcos Guilherme
Franchin, Marcelo
de Paula-Eduardo, Laila Facin
Freires, Irlan Almeida
Beutler, John A.
de Alencar, Severino Matias
Ikegaki, Masaharu
Machado Tabchoury, Cinthia Pereira
Cunha, Thiago Mattar
Rosalen, Pedro Luiz
Abstract: ent-Nemorosone is a benzophenone isolated from geopropolis from Melipona scutellaris whose biological properties remain unexplored. Herein, we evaluated the anti-inflammatory activity of ent-nemorosone by in vivo neutrophil migration and TNF-alpha quantification, as well as by in vitro TNF-alpha quantification, ERK 1/2 phosphorylation, NF-kB activation and nuclear translocation of p65 in stimulated macrophages. ent-Nemorosone was also tested for its antimicrobial effects against Streptococcus mutans biofilm adhesion, polysaccharide production, and viability ent-Nemorosone reduced the influx of neutrophils and TNF-alpha release into the peritoneal cavity of mice, as well as the in vitro TNF-alpha levels, ERK 1/2 phosphorylation, NF-kB activation and nuclear p65 translocation. Furthermore, this compound inhibited biofilm adhesion and reduced the amount of extra- and intracellular polysaccharides synthesized by S. mutans. Thus, ent-nemorosone showed promising anti-inflammatory activity by acting on TNF-alpha release in macrophages, as well as anti-biofilm properties by reducing S. mutans polysaccharide production. (C) 2016 Elsevier Ltd. All rights reserved.
ent-Nemorosone is a benzophenone isolated from geopropolis from Melipona scutellaris whose biological properties remain unexplored. Herein, we evaluated the anti-inflammatory activity of ent-nemorosone by in vivo neutrophil migration and TNF-alpha quantification, as well as by in vitro TNF-alpha quantification, ERK 1/2 phosphorylation, NF-kB activation and nuclear translocation of p65 in stimulated macrophages. ent-Nemorosone was also tested for its antimicrobial effects against Streptococcus mutans biofilm adhesion, polysaccharide production, and viability ent-Nemorosone reduced the influx of neutrophils and TNF-alpha release into the peritoneal cavity of mice, as well as the in vitro TNF-alpha levels, ERK 1/2 phosphorylation, NF-kB activation and nuclear p65 translocation. Furthermore, this compound inhibited biofilm adhesion and reduced the amount of extra- and intracellular polysaccharides synthesized by S. mutans. Thus, ent-nemorosone showed promising anti-inflammatory activity by acting on TNF-alpha release in macrophages, as well as anti-biofilm properties by reducing S. mutans polysaccharide production
Subject: Geopropolis
Ent-nemorosone
Anti-inflammatory
Anti-biofilm
Anti-inflamatórios
Country: Países Baixos
Editor: Elsevier
Citation: Journal Of Functional Foods. Elsevier Science Bv, v. 26, p. 27 - 35, 2016.
Rights: fechado
Identifier DOI: 10.1016/j.jff.2016.07.009
Address: https://www.sciencedirect.com/science/article/pii/S1756464616301888
Date Issue: 2016
Appears in Collections:FOP - Artigos e Outros Documentos

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