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Type: Artigo
Title: Cytotoxic prenylated indole alkaloid produced by the endophytic fungus Aspergillus terreus P63
Author: Gubiani, Juliana R.
Oliveira, Michele C. S.
Neponuceno, Ricardo A. R.
Camargo, Maria J.
Garcez, Walmir S.
Biz, Andressa R.
Soares, Marcos A.
Araujo, Angela R.
Bolzani, Vanderlan da S.
Lisboa, Helen C. F.
de Sousa Jr, Paulo T.
de Vasconcelos, Leonardo G.
Ribeiro, Tereza A. N.
de Oliveira, Juliana M.
Banzato, Thais P.
Lima, Carolina A.
Longato, Giovanna B.
Batista Jr, Joao M.
Berlinck, Roberto G. S.
Teles, Helder L.
Abstract: Prenyl indole alkaloids constitute a diverse class of natural products with complex chemical structures and potent biological activities. Investigation of the growth medium EtOAc extract produced by the endophytic fungus Aspergillus terreus P63 collected from roots of the grass Axonopus leptostachyus, yielded the prenylated indole alkaloid, giluterrin, bearing an unprecedented carbon skeleton. The structure of giluterrin was established by analysis of spectroscopic data and HRMS. The absolute configuration of giluterrin was determined by combination of electronic and vibrational circular dichroism analyses. Giluterrin presented antiproliferative profile for prostate (PC-3) and kidney (786-0) cancer cell lines
Subject: Fungo endofítico
Country: Holanda
Editor: Elsevier
Rights: Aberto
Identifier DOI: 10.1016/j.phytol.2019.06.003
Date Issue: 2019
Appears in Collections:IB - Artigos e Outros Documentos

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