Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/346544
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBombini, Mariana Freschi-
dc.contributor.authorunicampPeres, Fernando Augusto-
dc.contributor.authorunicampLapa, Aline Tamires-
dc.contributor.authorunicampMartin, Nailú Angélica Sinicato-
dc.contributor.authorunicampQuental, Beatriz Ricato-
dc.contributor.authorunicampPincelli, Ágatha de Souza Melo-
dc.contributor.authorunicampAmaral, Tiago Nardi-
dc.contributor.authorunicampGomes, Caroline Cristina-
dc.contributor.authorunicampDel Rio, Ana Paula Toledo-
dc.contributor.authorunicampMarques Neto, João Francisco-
dc.contributor.authorunicampCostallat, Lilian Tereza Lavras-
dc.contributor.authorunicampFernandes, Paula Teixeira-
dc.contributor.authorunicampCendes, Fernando-
dc.contributor.authorunicampRittner, Leticia-
dc.contributor.authorunicampAppenzeller, Simone-
dc.typeArtigopt_BR
dc.titleOlfactory function in systemic lupus erythematosus and systemic sclerosis: a longitudinal study and review of the literaturept_BR
dc.contributor.authorBombini, MF-
dc.contributor.authorPeres, FA-
dc.contributor.authorLapa, AT-
dc.contributor.authorSinicato, NA-
dc.contributor.authorQuental, BR-
dc.contributor.authorPincelli, ÁSM-
dc.contributor.authorAmaral, TN-
dc.contributor.authorGomes, CC-
dc.contributor.authorDel Rio, AP-
dc.contributor.authorMarques-Neto, JF-
dc.contributor.authorCostallat, LTL-
dc.contributor.authorFernandes, PT-
dc.contributor.authorCendes, F-
dc.contributor.authorRittner, L-
dc.contributor.authorAppenzeller, S-
dc.subjectAutoimunidadept_BR
dc.subject.otherlanguageAutoimmunitypt_BR
dc.description.abstractTo evaluate olfactory function in systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and healthy controls over a 2-year period, and to determine the association of olfactory dysfunction with age, disease activity, disease damage, treatment, anxiety and depression symptoms and limbic structures volumes. Consecutive SLE and SSc patients were enrolled in this study. Clinical, laboratory disease activity and damage were assessed according to diseases specific guidelines. Olfactory functions were evaluated using the Sniffin' Sticks test (TDI). Volumetric magnetic resonance imaging (MRI) was obtained in a 3T Phillips scanner. Amygdalae and hippocampi volumes were analyzed using FreeSurfer® software. We included 143 SLE, 57 SSc and 166 healthy volunteers. Olfactory dysfunction was observed in 78 (54.5%) SLE, 35 (59.3%) SSc patients and in 24 (14.45%) controls (p < 0.001) at study entry. SLE and SSc patients had significantly lower mean in all three phases (TDI) of the olfactory assessment when compared with healthy volunteers. In SLE, the presence of olfactory dysfunction was associated with older age, disease activity, higher anxiety and depression symptoms score, smaller left hippocampus volume, smaller left and right amygdalae volume and the presence of anti-ribosomal P (anti-P) antibodies. In SSc the presence of olfactory impairment was associated with older age, disease activity, smaller left and right hippocampi volumes and smaller right amygdala volume. Olfactory function was repeated after a 2-year period in 90 SLE, 35 SSc and 62 controls and was stable in all three groups. Both SLE and SSc patients with longstanding disease had significant reduction in all stages of TDI that maintained stable over a 2-year period. Olfactory dysfunction was associated with age, inflammation and hippocampi and amygdalae volumes. In SLE, additional association with anti-P, anxiety and depression symptoms was observedpt_BR
dc.relation.ispartofAutoimmunity reviewspt_BR
dc.relation.ispartofabbreviationAutoimmun. rev.pt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2018-
dc.date.monthofcirculationApr.pt_BR
dc.language.isoengpt_BR
dc.description.volume17pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage405pt_BR
dc.description.lastpage412pt_BR
dc.rightsFechadopt_BR
dc.sourcePUBMEDpt_BR
dc.identifier.issn1568-9972pt_BR
dc.identifier.eissn1873-0183pt_BR
dc.identifier.doi10.1016/j.autrev.2018.02.002pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1568997218300442pt_BR
dc.date.available2020-07-31T20:48:52Z-
dc.date.accessioned2020-07-31T20:48:52Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-07-31T20:48:52Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-07-31T20:48:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2018en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/346544-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Ciências do Esportept_BR
dc.contributor.departmentDepartamento de Neurologiapt_BR
dc.contributor.departmentDepartamento de Engenharia de Computação e Automação Industrialpt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Enfermagempt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Educação Físicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Engenharia Elétrica e de Computaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordSense of smellpt_BR
dc.subject.keywordOlfactionpt_BR
dc.subject.keywordOlfactory dysfunctionpt_BR
dc.subject.keywordCentral nervous system diseasespt_BR
dc.subject.keywordSystemic lupus erythematosuspt_BR
dc.subject.keywordSystemic sclerosispt_BR
dc.identifier.source29444467pt_BR
dc.creator.orcid0000-0003-1913-0510pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-8654-5620pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-3077-9479pt_BR
dc.creator.orcid0000-0002-0492-1670pt_BR
dc.creator.orcid0000-0001-9336-9568pt_BR
dc.creator.orcid0000-0001-8182-5554pt_BR
dc.creator.orcid0000-0001-5075-4474pt_BR
dc.type.formArtigo de revisãopt_BR
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