Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/349455
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCazarin, Cínthia Baú Betim-
dc.contributor.authorunicampLamas, Celina de Almeida-
dc.contributor.authorunicampCagnon, Valéria Helena Alves-
dc.contributor.authorunicampMorari, Joseane-
dc.contributor.authorunicampVelloso, Licio Augusto-
dc.contributor.authorunicampMaróstica Junior, Mário Roberto-
dc.typeArtigopt_BR
dc.titleGrape peel powder attenuates the inflammatory and oxidative response of experimental colitis in rats by modulating the NF-κB pathway and activity of antioxidant enzymespt_BR
dc.contributor.authorMaurer, Luana H.-
dc.contributor.authorCazarin, Cinthia B. B.-
dc.contributor.authorQuatrin, Andréia-
dc.contributor.authorMinuzzi, Natália M.-
dc.contributor.authorNichelle, Sabrina M.-
dc.contributor.authorLamas, Celina de A.-
dc.contributor.authorCagnon, Valéria H. A.-
dc.contributor.authorMorari, Joseane-
dc.contributor.authorVelloso, Lício A.-
dc.contributor.authorMaróstica Júnior, Mário R.-
dc.contributor.authorEmanuelli, Tatiana-
dc.subjectInflamaçãopt_BR
dc.subject.otherlanguageInflammationpt_BR
dc.description.abstractMost phenolic compounds and dietary fiber reach intact to the colon. We hypothesized that grape peel powder (GPP), a rich source of these bioactive compounds, modulates inflammatory and oxidative pathways collaborating to attenuate colonic damage in experimental colitis. To determine which bioactive fraction would be responsible for this effect, the aim of this study was to evaluate the effect of dietary supplementation with whole GPP or the isolated bioactive-rich fractions from GPP (extractable polyphenols [EP], dietary fiber and fiber-bound polyphenols [NEP-F], and dietary fiber) in rats with experimental colitis. Colitis was induced by intrarectal injection of 2,4,6-trinitrobenzene sulfonic acid (TNBS) after 15 days of dietary supplementation. EP diet did not reverse the decrease in feed intake and indeed worsened colon shortening and increased spleen weight; however, these effects were not observed for the GPP group, which had polyphenols associated to the matrix besides the extractable ones. Colitis impaired the activity of colonic antioxidant enzymes and increased lipid peroxidation, protein oxidation, nitric oxide (NO) levels, and proinflammatory cytokines in serum and in the colon tissue. GPP restored the activity of antioxidant enzymes and decreased colon oxidation and NO levels. All grape peel fractions reduced the protein expression of the inhibitor of kappa kinase beta and NO levels in colon tissue, but only NEP-F reduced the expression of phosphorylated nuclear factor kappa B and myeloperoxidase activity. Results demonstrated that GPP attenuates inflammatory and oxidative response in TNBS–induced colitis by downregulating the nuclear factor kappa B pathway and upregulating antioxidant enzymes, with NEP-F being the fraction most likely associated to these protective effectspt_BR
dc.relation.ispartofNutrition researchpt_BR
dc.relation.ispartofabbreviationNutr. res.pt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2020-
dc.date.monthofcirculationApr.pt_BR
dc.language.isoengpt_BR
dc.description.volume76pt_BR
dc.description.firstpage52pt_BR
dc.description.lastpage70pt_BR
dc.rightsFechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn0271-5317pt_BR
dc.identifier.eissn1879-0739pt_BR
dc.identifier.doi10.1016/j.nutres.2020.01.006pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0271531719307985pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsordocumentnumber552440/2011-6; 309227/2013-5; 458664/2014-6; 301108/2016-1pt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2020-09-16T21:04:27Z-
dc.date.accessioned2020-09-16T21:04:27Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2020-09-16T21:04:27Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-09-16T21:04:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/349455-
dc.contributor.departmentDepartamento de Alimentos e Nutriçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentDepartamento de Alimentos e Nutriçãopt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Engenharia de Alimentospt_BR
dc.subject.keywordMatrix-bound polyphenolspt_BR
dc.subject.keywordDietary fiberpt_BR
dc.subject.keywordPeroxynitritept_BR
dc.identifier.source2-s2.0-85081571177pt_BR
dc.creator.orcid0000-0002-9849-2546pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-5331-7376pt_BR
dc.creator.orcid0000-0002-0728-4283pt_BR
dc.creator.orcid0000-0002-4806-7218pt_BR
dc.creator.orcid0000-0001-8877-3160pt_BR
dc.type.formArtigopt_BR
Appears in Collections:IB - Artigos e Outros Documentos
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