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Type: Artigo de periódico
Title: (R)-goniothalamin: total syntheses and cytotoxic activity against cancer cell lines
Author: de Fatima, A
Kohn, LK
Antonio, MA
de Carvalho, JE
Pilli, RA
Abstract: The total syntheses of (R)-goniothalamin (1), a styryl lactone isolated from several Goniothalamus species, via catalytic asymmetric allylation of alpha-benzyloxyacetaldehyde (2), followed by ring-closing metathesis and Wittig olefination and via catalytic asymmetric allylation of trans-cinnamaldehyde (12), followed by ring-closing metathesis are reported. The anti proliferative activities of (R)-1 and its Z-isomer 10 as well as of the synthetic dihydropyranone intermediates 7 and 8 against eight different cancer cell lines are also described. (c) 2005 Elsevier Ltd. All rights reserved.
Subject: (R)-goniothalamin
asymmetric synthesis
cytotoxic activity
cancer cells
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Bioorganic & Medicinal Chemistry. Pergamon-elsevier Science Ltd, v. 13, n. 8, n. 2927, n. 2933, 2005.
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2005.02.007
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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