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Type: Artigo de periódico
Title: Anaemia in patients with cancer: role of inflammatory activity on iron metabolism and severity of anaemia
Author: Jacober, MLV
Mamoni, RL
Lima, CSP
dos Anjos, BL
Grotto, HZW
Abstract: Hepcidin has been proposed as an important factor in the pathogenesis of the anaemia of chronic disease (ACD). The aim of this study was to assess the relationship between anaemia and inflammatory activity in patients with solid tumours. Patients were classified as having iron deficiency anaernia (IDA) (hypoferremia and hypoferretinemia), ACD (hypoferremia, normal or increased serum ferritin) and anaemia related to cancer (ARC) (no abnormalities in iron status). Serum pro-hepcidin, IL-6, C-reactive protein (CRP) and iron status parameters were measured using commercial kits. CRP and IL-6 levels were significantly higher in patients with ACD when compared to IDA, ARC and non anaemic patients (P < 0.005). Serum pro-hepcidin levels were not different among all studied groups (P = 0.138). A negative correlation was observed between haemoglobin and serum ferritin, CRP and IL-6 levels only in group of ACD. Serum pro-hepcidin concentrations were not correlated with degree of anaemia or iron metabolism parameters. According to our results the inflammatory activity represented by high levels of IL-6 and CRP are involved in the pathogenesis of ACD, probably due to the action of inflammation on iron metabolism, but not in ARC. It was not possible to demonstrate a significant effect of pro-hepcidin on the anaemia in cancer patients.
Subject: anaemia of chronic disease
C-reactive protein
iron metabolism
Country: EUA
Editor: Humana Press Inc
Citation: Medical Oncology. Humana Press Inc, v. 24, n. 3, n. 323, n. 329, 2007.
Rights: fechado
Identifier DOI: 10.1007/s12032-007-0009-9
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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