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|Type:||Artigo de periódico|
|Title:||Coumarins from Free ortho-Hydroxy Cinnamates by Heck-Matsuda Arylations: A Scalable Total Synthesis of (R)-Tolterodine|
|Abstract:||Free ortho-hydroxy cinnamate ester derivatives are evaluated in the synthesis of structurally diverse 4-aryl-coumarins via a tandem Heck-Matsuda cyclization reaction. Free phenolic groups were considered incompatible with such a reaction, which usually provide the corresponding diazo dyes. A concise and scalable route employing a ligand-free, Pd-catalyzed Heck-Matsuda arylation under aerobic conditions for the preparation of (R)-Tolterodine in high overall yield and ee is also presented.|
|Editor:||Amer Chemical Soc|
|Citation:||Organic Letters. Amer Chemical Soc, v. 14, n. 23, n. 6036, n. 6039, 2012.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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