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Type: Artigo de periódico
Title: Coumarins from Free ortho-Hydroxy Cinnamates by Heck-Matsuda Arylations: A Scalable Total Synthesis of (R)-Tolterodine
Author: Barancelli, DA
Salles, AG
Taylor, JG
Correia, CRD
Abstract: Free ortho-hydroxy cinnamate ester derivatives are evaluated in the synthesis of structurally diverse 4-aryl-coumarins via a tandem Heck-Matsuda cyclization reaction. Free phenolic groups were considered incompatible with such a reaction, which usually provide the corresponding diazo dyes. A concise and scalable route employing a ligand-free, Pd-catalyzed Heck-Matsuda arylation under aerobic conditions for the preparation of (R)-Tolterodine in high overall yield and ee is also presented.
Country: EUA
Editor: Amer Chemical Soc
Citation: Organic Letters. Amer Chemical Soc, v. 14, n. 23, n. 6036, n. 6039, 2012.
Rights: fechado
Identifier DOI: 10.1021/ol302923f
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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