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Type: Artigo de periódico
Title: Cutaneous Metastasis From a Classic Papillary Thyroid Cancer With Positive Immunohistochemical Staining for Sodium Iodide Symporter but No Response to Radioiodine Therapy
Author: Ward, LS
Rezende, CAC
Morari, EC
Camacho, E
Vassallo, J
Abstract: A 76-year-old man presented with small reddish, painless nodular lesions of the chest and on neck surgical scars. The patient had, 5 years before, a T3N1M0 classic papillary thyroid carcinoma that evolved with recurrent cervical lymph node metastasis despite 3 surgeries and a cumulative dose of 500 mCi of (131)Iodine. Investigations included the lesion biopsy and Tg immunohistochemistry, which led to the diagnosis of rare skin metastasis from a well differentiated thyroid tumor. The cutaneous lesions also tested positive for sodium iodide symporter protein, with clear membrane immunohistochemical staining. However, the patient did not respond to an additional dose of 400 mCi of radioiodine, suggesting a nonfunctional sodium iodide symporter protein. The lesions rapidly spread to the chest wall and erythematous red-purple inflamed nodules became confluent over a 3-month period. The tumor invaded the trachea causing the patient's death.
Subject: differentiated thyroid carcinoma
molecular markers
Country: EUA
Editor: Lippincott Williams & Wilkins
Citation: Endocrinologist. Lippincott Williams & Wilkins, v. 19, n. 5, n. 214, n. 217, 2009.
Rights: fechado
Identifier DOI: 10.1097/TEN.0b013e3181b5aa91
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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