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Type: Artigo de periódico
Title: Cyclosporin A and Bcl-2 do not inhibit quinolinic acid-induced striatal excitotoxicity in rodents
Author: Maciel, EN
Schierle, GSK
Hansson, O
Brundin, P
Castilho, RF
Abstract: Mitochondrial permeability transition (MPT) is a nonselective inner membrane permeabilization that contributes to neuronal cell death under circumstances such as brain trauma, ischemia, and hypoglycemia. Here we study the participation of MPT and the Bcl-2-sensitive apoptotic cell death pathway in glutamate receptor-mediated excitotoxicity. Intrastriatal infusions of the N-methyl-D-aspartate (NMDA) receptor agonist quinolinic acid caused massive striatal neurodegeneration in both rats and mice. Interestingly, transgenic mice overexpressing human Bcl-2 and rats systemically treated with cyclosporin A did not exhibit reduced sensitivity to quinolinic acid-induced striatal toxicity. Both Bcl-2 and cyclosporin A are inhibitors of MPT; in addition Bcl-2 also inhibits apoptotic stimuli-mediated release of mitochondrial apoptogenic factors. Isolated brain mitochondria from cyclosporin A-treated rats showed resistance to Ca2+-induced dissipation of the membrane potential, indicating protection against MPT. We conclude that quinolinic acid-mediated striatal excitotoxicity is not dependent on MPT and Bcl-2-sensitive apoptotic cell death pathways. (C) 2003 Elsevier Science (USA). All rights reserved.
Subject: Bcl-2
cyclosporin A
mitochondrial permeability transition
quinolinic acid
Country: EUA
Editor: Academic Press Inc Elsevier Science
Citation: Experimental Neurology. Academic Press Inc Elsevier Science, v. 183, n. 2, n. 430, n. 437, 2003.
Rights: fechado
Identifier DOI: 10.1016/S0014-4886(03)00165-1
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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