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Type: Artigo de periódico
Title: Pulmonary involvement in ankylosing spondylitis
Author: Sampaio-Barros, PD
Cerqueira, EMFP
Rezende, SM
Maeda, L
Conde, RA
Zanardi, VA
Bertolo, MB
Neto, JRD
Samara, AM
Abstract: This is a prospective study analyzing 52 asymptomatic, consecutive patients with ankylosing spondylitis (AS), who submitted to a pulmonary investigation that included plain chest radiography, pulmonary function test (PFT), and thoracic high-resolution computed tomography (HRCT). The results were compared according to sex, race, dorsal spine involvement, thoracic diameter, smoking status, and HLA-B27. There were four patients (8%) with an altered plain chest radiograph. PFT presented a restrictive pattern in 52% of the patients. Thoracic HRCT showed abnormalities in 21 patients (40%), predominantly nonspecific linear parenchymal opacities (19%), lymphadenopathy (12%), emphysema (10%), bronchiectasis (8%), and pleural involvement (8%). Linear parenchymal opacities were associated with a smoking history (p=0.026) and dorsal spine involvement (p=0.032). HLA-B27 was not associated with any abnormality. A lower thoracic diameter was observed in patients with dorsal spine involvement (p=0.0001), restrictive pattern at PFT (p=0.023), and linear parenchymal opacities (p=0.015). The study concluded that nonspecific subclinical pulmonary involvement is frequent in AS.
Subject: ankylosing spondylitis
high-resolution computed tomography
lung involvement
pulmonary function test
Country: EUA
Editor: Springer
Citation: Clinical Rheumatology. Springer, v. 26, n. 2, n. 225, n. 230, 2007.
Rights: fechado
Identifier DOI: 10.1007/s10067-006-0286-2
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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