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Type: Artigo de periódico
Title: Ozonolysis of Morita-Baylis-Hillman adducts originated from aromatic aldehydes: an expeditious diastereoselective approach for the preparation of alpha,beta-dihydroxy-esters
Author: Abella, CAM
Rezende, P
de Souza, MFL
Coelho, F
Abstract: We disclose herein ozonolysis of Morita-Baylis-Hillman adducts originated from aromatic aldehydes. This efficient reaction provides alpha-ketoesters with different substitution patterns on the aromatic ring. Diastercoselective reduction of the corresponding alpha-ketoester obtained in the oxidative cleavage step provides alpha,beta-dihydroxy-esters with excellent degree of anti diastereoselection. The method is simple and easy to execute and is therefore a valuable alternative to prepare either alpha-ketoesters or alpha-dihydroxy-esters. (c) 2007 Elsevier Ltd. All rights reserved.
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 49, n. 1, n. 145, n. 148, 2008.
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2007.10.149
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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