Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/59410
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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePharmacological characterization of Solanum cernuum Vell.: 31-norcycloartanones with analgesic and anti-inflammatory propertiespt_BR
dc.contributor.authorLopes, LCpt_BR
dc.contributor.authorde Carvalho, JEpt_BR
dc.contributor.authorKakimore, Mpt_BR
dc.contributor.authorVendramini-Costa, DBpt_BR
dc.contributor.authorMedeiros, MApt_BR
dc.contributor.authorSpindola, HMpt_BR
dc.contributor.authorAvila-Roman, Jpt_BR
dc.contributor.authorLourenco, AMpt_BR
dc.contributor.authorMotilva, Vpt_BR
unicamp.author.emailmotilva@us.espt_BR
unicamp.authorLopes, Luciane C. Kakimore, Marise Univ Sorocaba, UNISO, Programa Posgrad Strictu Senso Ciencias Farmaceut, BR-18023000 Sorocaba, SP, Brazilpt_BR
unicamp.authorde Carvalho, Joao Ernesto Vendramini-Costa, Debora B. Spindola, Humberto M. Univ Estadual Campinas, CPQBA Ctr Pluridisciplinar Pesquisas Quim Biol &, UNICAMP, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorMedeiros, Maria A. Lab Nacl Energia & Geol IP, UESEO, P-1649038 Lisbon, Portugalpt_BR
unicamp.authorAvila-Roman, Javier Motilva, Virginia Univ Seville, Fac Farm, Dept Farmacol, Seville 41010, Spainpt_BR
unicamp.authorLourenco, Ana M. Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE, P-2829516 Caparica, Portugalpt_BR
dc.subjectSolanum cernuum Vell.pt_BR
dc.subject31-Norcycloartanonespt_BR
dc.subjectAnalgesicpt_BR
dc.subjectAnti-inflammatorypt_BR
dc.subjectCOX-2pt_BR
dc.subject.wosNf-kappa-bpt_BR
dc.subject.wosInhibitionpt_BR
dc.subject.wosPathwayspt_BR
dc.subject.wosProductspt_BR
dc.subject.wosMicept_BR
dc.description.abstractCycloeucalenone (1) and 24-oxo-31-norcycloartanone (2) obtained from Solanum cernuum Vell. were assayed to explore their pharmacologic roles. Previous studies showed that (2) has selective activity against lung tumor cell line (NCIH460) which expresses high levels of COX-2, suggesting its role in inflammatory process, and also a link between chronic inflammation and cancer-associated process. Dichloromethane crude extract (DCE) significantly reduced writhing and stretching induced by 0.8 % acetic acid at a dose of 100, 300, and 600 mg/kg, po; oral administration of different doses of (1) and (2) also displayed significant analgesic and anti-inflammatory effects in the writhing acetic acid test (p < 0.0001). Selected oral doses of both compounds (100 and 50 mg/kg) were assayed in the carrageenan-induced paw edema model. Compound (2) showed significant activity during the early phase (1.5-6 h) and also in the late phase (48 h) (p < 0.01). The anti-nociceptive activity observed for the compounds (1) and (2) and DCE was found to be related to the inhibition of different mediators involved in inflammation and nociceptive process. Both compounds decrease COX-2 protein expression, although only compound (2) reached a significant response (p < 0.05 vs control). However, in vitro Sirtuin 1 activity and TNF-alpha production in THP-1 macrophages were not affected.pt
dc.relation.ispartofInflammopharmacologypt_BR
dc.relation.ispartofabbreviationInflammopharmacologypt_BR
dc.publisher.cityBaselpt_BR
dc.publisher.countrySuíçapt_BR
dc.publisherSpringer Basel Agpt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationJUNpt_BR
dc.identifier.citationInflammopharmacology. Springer Basel Ag, v. 22, n. 3, n. 179, n. 185, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume22pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage179pt_BR
dc.description.lastpage185pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0pt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0925-4692pt_BR
dc.identifier.eissn1568-5608pt_BR
dc.identifier.wosidWOS:000336394200004pt_BR
dc.identifier.doi10.1007/s10787-013-0182-8pt_BR
dc.description.sponsorshipAndalucia Government, Spain - Proyecto de Excelencia-Polfanat [P09-AGR- 5185]pt_BR
dc.description.sponsorshipPrograma de Mestrado em Uso Racional de Medicamentos of the Universidade de Sorocaba (Brazil)pt_BR
dc.description.sponsordocumentnumberAndalucia Government, Spain - Proyecto de Excelencia-Polfanat [P09-AGR- 5185]pt
dc.date.available2014-07-30T14:31:23Z
dc.date.available2015-11-26T16:49:04Z-
dc.date.accessioned2014-07-30T14:31:23Z
dc.date.accessioned2015-11-26T16:49:04Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:31:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:49:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59410
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59410-
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