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Type: Artigo de periódico
Title: Increased levels of rheumatoid factors after TNF inhibitor in rheumatoid arthritis
Author: Mendonca, JA
Marques-Neto, JF
Samara, AM
Appenzeller, S
Abstract: Targeted inhibition of tumor necrosis factor-alpha (TNF-alpha) is an effective therapy in rheumatoid arthritis (RA). In some rare cases, autoimmune phenomena, including drug-induced lupus and vasculitis, is described. However, the immunological mechanisms underlying the development of autoimmunity are unknown. We report 3 patients that developed autoimmune phenomena while in use of TNF-alpha inhibitor, showing concomitant increase in rheumatoid factor (RF). We hypothesize that the increase in RF several months prior to the occurrence of vasculitis may help identifying other patients at risk for the development of vasculitis secondary to these medications.
Subject: Rheumatoid factor
Rheumatoid arthritis
TNF-alpha inhibitors
Country: Alemanha
Editor: Springer Heidelberg
Citation: Rheumatology International. Springer Heidelberg, v. 32, n. 3, n. 815, n. 818, 2012.
Rights: fechado
Identifier DOI: 10.1007/s00296-011-1812-3
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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