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Type: Artigo de periódico
Title: Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer
Author: Cunha, LL
Tincani, AJ
da Assumpcao, LVM
Soares, FA
Vassallo, J
Ward, LS
Abstract: OBJECTIVES: The aim of this study was to investigate the role of the interleukin-18 + 105A/C and interleukin-10-1082A/G germline polymorphisms in the development and outcome of differentiated thyroid carcinoma associated or not with concurrent thyroiditis. METHODS: We studied 346 patients with differentiated thyroid carcinomas, comprising 292 papillary carcinomas and 54 follicular carcinomas, who were followed up for 12-298 months ( mean 76.10 +/- 68.23 months) according to a standard protocol. We genotyped 200 patients and 144 control individuals for the interleukin-18 + 105A/C polymorphism, and we genotyped 183 patients and 137 controls for the interleukin-10-1082A/G polymorphism. RESULTS: Interleukin-18 polymorphisms were not associated with chronic lymphocytic thyroiditis or any clinical or pathological feature of tumor aggressiveness. However, there was an association between the presence of interleukin-10 variants and chronic lymphocytic thyroiditis. Chronic lymphocytic thyroiditis was present in 21.74% of differentiated thyroid carcinoma patients, most frequently affecting women previously diagnosed with Hashimoto's thyroiditis who had received a lower I-131 cumulative dose and did not present lymph node metastases. CONCLUSIONS: We conclude that the inheritance of a G allele at the interleukin-10 - 1082A/G polymorphism may favor a concurrent thyroid autoimmunity in differentiated thyroid carcinoma patients, and this autoimmunity may favor a better prognosis for these patients.
Subject: Tumor immunity
Chronic lymphocytic thyroiditis
Country: Brasil
Editor: Hospital Clinicas, Univ Sao Paulo
Citation: Clinics. Hospital Clinicas, Univ Sao Paulo, v. 66, n. 7, n. 1203, n. 1208, 2011.
Rights: aberto
Identifier DOI: 10.1590/S1807-59322011000700014
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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