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Type: Artigo de periódico
Title: Intrinsic laryngeal muscles are spared from myonecrosis in the mdx mouse model of duchenne muscular dystrophy
Author: Marques, MJ
Ferretti, R
Vomero, VU
Minatel, E
Neto, HS
Abstract: Intrinsic laryngeal muscles share many anatomical and physiological properties with extraocular muscles, which are unaffected in both Duchenne muscular dystrophy and mdx mice. We hypothesized that intrinsic laryngeal muscles are spared from myonecrosis in mdx mice and may serve as an additional tool to understand the mechanisms of muscle sparing in dystrophinopathy. Intrinsic laryngeal muscles and tibialis anterior (TA) muscle of adult and aged mdxand control C57BI/10 mice were investigated. The percentage of central nucleated fibers, as a sign of muscle fibers that had undergone injury and regeneration, and myofiber labeling with Evans blue dye, as a marker of myofiber damage, were studied. Except for the cricothyroid muscle, none of the intrinsic. laryngeal muscles from adult and old mdx mice showed signs of myofiber damage or Evans blue dye labeling, and all appeared to be normal. Central nucleation was readily visible in the TA of the same mdx mice. A significant increase in the percentage of central nucleated fibers was observed in adult cricothyroid muscle compared to the other intrinsic laryngeal muscles, which worsened with age. Thus, we have shown that the intrinsic laryngeal muscles are spared from the lack of dystrophin and may serve as a useful model to study the mechanisms of muscle sparing in dystrophinopathy.
Subject: aging
intrinsic laryngeal muscles
mdx mouse
muscle regeneration
Country: EUA
Editor: John Wiley & Sons Inc
Citation: Muscle & Nerve. John Wiley & Sons Inc, v. 35, n. 3, n. 349, n. 353, 2007.
Rights: fechado
Identifier DOI: 10.1002/mus.20697
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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