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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleInvestigation of IL4 gene polymorphism in individuals with different levels of chronic periodontitis in a Brazilian populationpt_BR
dc.contributor.authorScarel-Caminaga, RMpt_BR
dc.contributor.authorTrevilatto, PCpt_BR
dc.contributor.authorSouza, APpt_BR
dc.contributor.authorBrito, RBpt_BR
dc.contributor.authorLine, SRPpt_BR
unicamp.authorUNICAMP, Fac Odontol Piracicaba, Dept Morfol, Dent Sch Piracicaba, BR-13414018 Piracicaba, SP, Brazil Univ Sacred Heart, Bauru, SP, Brazilpt_BR
dc.subjectIL4pt_BR
dc.subjectpolymorphismpt_BR
dc.subjectchronic periodontitispt_BR
dc.subjectrisk factorspt_BR
dc.subject.wosGingival Crevicular Fluidpt_BR
dc.subject.wosNecrosis-factor-alphapt_BR
dc.subject.wosInterleukin-4 Genept_BR
dc.subject.wosB-cellspt_BR
dc.subject.wosDiseasept_BR
dc.subject.wosAsthmapt_BR
dc.subject.wosPromoterpt_BR
dc.subject.wosAssociationpt_BR
dc.subject.wosExpressionpt_BR
dc.subject.wosCytokinespt_BR
dc.description.abstractBackground: Cytokines are key factors that mediate the inflammatory process during periodontal disease. Recent works have shown that the levels of cytokine expression are regulated by genetic polymorphisms, and that these variations can interfere with the progression of disease. The-590 (C-->T) polymorphism of the IL4 gene is associated with high levels of IgE in asthmatic families, and the frequency of the T allele was increased in asthmatic children. The concentration of IgE in gingival tissue was found to be elevated in patients with periodontitis. Objective: In this study the relationship between the-590 (C-->T) polymorphism in the IL4 gene and different levels of chronic periodontal disease was investigated. Material and Methods: DNA was extracted from buccal epithelial cells of 113 unrelated adult individuals with different levels of periodontitis. The PCR-RFLP technique was used to investigate the polymorphism in the promoter of IL4 gene. Results: No significant differences in the allele and genotype frequencies of the polymorphism were found between control and groups with periodontal disease. Conclusion: We conclude that the-590 (C-->T) polymorphism in the IL4 gene is not associated with the susceptibility to chronic periodontal disease.pt
dc.relation.ispartofJournal Of Clinical Periodontologypt_BR
dc.relation.ispartofabbreviationJ. Clin. Periodontol.pt_BR
dc.publisher.cityCopenhagenpt_BR
dc.publisher.countryDinamarcapt_BR
dc.publisherBlackwell Munksgaardpt_BR
dc.date.issued2003pt_BR
dc.date.monthofcirculationAPRpt_BR
dc.identifier.citationJournal Of Clinical Periodontology. Blackwell Munksgaard, v. 30, n. 4, n. 341, n. 345, 2003.pt_BR
dc.language.isoenpt_BR
dc.description.volume30pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage341pt_BR
dc.description.lastpage345pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0303-6979pt_BR
dc.identifier.wosidWOS:000182259200009pt_BR
dc.identifier.doi10.1034/j.1600-051X.2003.00317.xpt_BR
dc.date.available2014-11-17T03:44:37Z
dc.date.available2015-11-26T16:37:17Z-
dc.date.accessioned2014-11-17T03:44:37Z
dc.date.accessioned2015-11-26T16:37:17Z-
dc.description.provenanceMade available in DSpace on 2014-11-17T03:44:37Z (GMT). No. of bitstreams: 1 WOS000182259200009.pdf: 95442 bytes, checksum: 085c11bec86d962e64f6c284d558ea57 (MD5) Previous issue date: 2003en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:37:17Z (GMT). No. of bitstreams: 2 WOS000182259200009.pdf: 95442 bytes, checksum: 085c11bec86d962e64f6c284d558ea57 (MD5) WOS000182259200009.pdf.txt: 30676 bytes, checksum: 1d2472b961017d139028b0b19f31ac3b (MD5) Previous issue date: 2003en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60617pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/60617
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60617-
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