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Type: Artigo de periódico
Title: Lack of Arg972 polymorphism in the IRS1 gene in Parakand Brazilian Indians
Author: Bezerra, RMN
Chadid, TT
Altemani, CM
Sales, TSI
Menezes, R
Soares, MCP
Saad, STO
Saad, MJA
Abstract: Several polymorphisms in the insulin receptor substrate-1 (IRS1) gene have been reported in the last years. The most common IRS1 variant, a Gly --> Arg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations. To determine whether the absence of IRS1 polymorphism is a more general characteristic of Paleo-Indian-derived populations, we examined the Arg972 IRS1 polymorphism in Parakana Indians and found a lack of this polymorphism in the Parakana population.
Subject: IRSI (insulin receptor substrate-1 gene)
ARG972 polymorphism
Parakana Indians
Pima Indians
insulin resistance
Country: EUA
Editor: Wayne State Univ Press
Citation: Human Biology. Wayne State Univ Press, v. 76, n. 1, n. 147, n. 151, 2004.
Rights: embargo
Identifier DOI: 10.1353/hub.2004.0015
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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