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|Type:||Artigo de periódico|
|Title:||Developmental language disorder associated with polymicrogyria|
|Abstract:||Background: Subtle disorders of neuronal migration occur in the brains of some dyslexic patients who presented developmental language disorder (DLD) during early childhood. Objective: To investigate a possible neuroanatomical substrate based on neuroimaging evaluation in children with DLD. Methods: The authors obtained psychological assessment, language evaluation, neurologic examination, and neuroimaging investigation. Inclusion criteria were as follows: children should be at least 4 years of age; primary complaint of language delay; normal hearing; IQ >70; and an informed consent form signed by parents or guardians. Exclusion criteria were severe motor and cognitive handicap. Results: Fifteen children met all inclusion criteria. Ages ranged from 4 to 14 years and 11 were boys. Six patients presented diffuse polymicrogyria (PMG) around the entire extent of the sylvian fissure on MRI, and they had severe clinical manifestation of DLD: they did not speak at all or had mixed phonologic-syntactic deficit syndrome. Six children presented PMG restricted to the posterior aspects of the parietal regions, and they had a milder form of DLD: mainly phonologic programming deficit syndrome. The other three children had different imaging findings. Conclusions: Developmental language disorder can be associated with polymicrogyria and the clinical manifestation varies according to the extension of cortical abnormality. A subtle form of posterior parietal polymicrogyria presenting as developmental language disorder is a mild form of perisylvian syndrome.|
|Editor:||Lippincott Williams & Wilkins|
|Citation:||Neurology. Lippincott Williams & Wilkins, v. 59, n. 2, n. 245, n. 250, 2002.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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