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Type: Artigo de periódico
Title: Diagnosis of mycosis fungoides - A comparative immunohistochemical study of T-cell markers using a novel anti-CD7 antibody
Author: Cotta, AC
Cintra, ML
de Souza, EM
Chagas, CA
Magna, LA
Fleury, RN
Brousset, P
Vassallo, J
Abstract: Mycosis fungoides (MF) is the most common form of primary cutaneous T-cell lymphoma. In its early stage it may mimic benign dermatoses both on a clinical and histologic basis. MF usually expresses CD3 and CD4 (T-cell) markers. CD7 is expressed on about 90% of CD4(+) T cells and is often deficient on malignant T cells. Thus, CD7 may be useful in evaluating the nature of dermal lymphoid infiltrates. The aim of this study was to evaluate the usefulness of immunohistochemical detection of T-cell markers on paraffin-embedded sections, CD3 and CD7 (clone CBC.37), in the differential diagnosis of MF and benign dermatoses. Forty-two patients with diffuse dermal T-lymphocytic infiltrates were selected. Previous clinicoputhologic correlation and follow-up had established the diagnosis of MF in 31 patients and benign dermatoses in 11. The mean value of stained cells in MF was 86.45% for CD3 and 53.09% for CD7 (P < 0.001); in benign dermatoses it was 79.09% for CD3 and 73.63% for CD7 (P = 0.669). CD7 immunolabeling was significantly lower in the MF group (P = 0.048). A semiquantitative evaluation revealed a considerable loss of CD7 immunolabeling in comparison with CD3 in patients with MF. The authors conclude that CD7 study may represent a valuable tool in the distinction between inflammation and neoplasia in T-lymphoproliferative skin disorders.
Subject: mycosis fungoides
differential diagnosis
Country: EUA
Editor: Lippincott Williams & Wilkins
Citation: Applied Immunohistochemistry & Molecular Morphology. Lippincott Williams & Wilkins, v. 14, n. 3, n. 291, n. 295, 2006.
Rights: fechado
Identifier DOI: 10.1097/00129039-200609000-00006
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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