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Type: Artigo de periódico
Title: Effect of Genetic Polymorphisms of Vascular Endothelial Growth Factor on Left Ventricular Hypertrophy in Patients With Systemic Hypertension
Author: Lacchini, R
Luizon, MR
Gasparini, S
Ferreira-Sae, MC
Schreiber, R
Nadruz, W
Tanus-Santos, JE
Abstract: Vascular endothelial growth factor (VEGF) is a cytokine involved in angiogenesis and upregulated during adaptive heart hypertrophy. Downregulation of VEGF seems to trigger the transition from adaptive to dilated cardiac hypertrophy. We investigated for the first time whether 3 clinically relevant polymorphisms in the VEGFA gene are associated with altered echocardiographic parameters in hypertensive patients. We determined genotypes for 3 polymorphisms in VEGFA promoter in 179 hypertensive patients and 169 healthy controls: g.-2578C>A (rs699947), g.-1154G>A (rs1570360), and g.-634G>C (rs2010963). Although the variant genotypes of the g.-634G>C (GC + CC) were associated with reduced left ventricular mass index (p = 0.030), the variant genotypes for the g.-1154G>A (GA + AA) were associated with reduced ejection fraction (p = 0.008). In addition, we found that VEGFA haplotypes were associated with altered ejection fraction (p = 0.024). The AAG haplotype was associated with reduced ejection fraction (p = 0.006), whereas the AGG haplotype was associated with increased ejection fraction (p = 0.010). Our results suggest that VEGF polymorphisms affect cardiac remodeling. Genotypes for VEGFA polymorphisms can be useful to help to identify hypertensive patients at greater intrinsic risk for heart failure. (C) 2014 Elsevier Inc. All rights reserved.
Country: EUA
Editor: Excerpta Medica Inc-elsevier Science Inc
Citation: American Journal Of Cardiology. Excerpta Medica Inc-elsevier Science Inc, v. 113, n. 3, n. 491, n. 496, 2014.
Rights: fechado
Identifier DOI: 10.1016/j.amjcard.2013.10.034
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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