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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEnalapril therapy and cardiac remodelling in sickle cell disease patientspt_BR
dc.contributor.authorLima, CSPpt_BR
dc.contributor.authorUeti, OMpt_BR
dc.contributor.authorUeti, AApt_BR
dc.contributor.authorFranchini, KGpt_BR
dc.contributor.authorCosta, FFpt_BR
dc.contributor.authorSaad, STOpt_BR
unicamp.author.emailcarmenl@fcm.unicamp.brpt_BR
unicamp.authorLima, Carmen S. P. Ueti, Osvaldo M. Ueti, Adriana A. Franchini, Kleber G. Costa, Fernando F. Saad, Sara T. O. Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.authorLima, Carmen S. P. Costa, Fernando F. Saad, Sara T. O. Univ Estadual Campinas, Fac Med Sci, Haematol & Haemotherapy Ctr, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectsickle cell diseasept_BR
dc.subjectACEipt_BR
dc.subjectenalaprilpt_BR
dc.subjectcardiac remodellingpt_BR
dc.subject.wosAngiotensin-converting Enzymept_BR
dc.subject.wosGlomerular-filtration-ratept_BR
dc.subject.wosDiastolic Dysfunctionpt_BR
dc.subject.wosAnemiapt_BR
dc.subject.wosHeartpt_BR
dc.subject.wosAlbuminuriapt_BR
dc.subject.wosNephropathypt_BR
dc.subject.wosCaptoprilpt_BR
dc.subject.wosFeaturespt_BR
dc.subject.wosChildrenpt_BR
dc.description.abstractIntroduction - Angiotensin-converting enzyme inhibitors (ACEi) have been successfully used for patients with cardiac dysfunction after myocardial infarction. Objective - The aim of the present study was to investigate cardiac effects of ACEi in sickle cell disease (SCD) patients, as there are no previous reports regarding these effects. Methods - Enalapril was administered to 9 SCD patients with microalbuminuria. Nine SCD patients without microalbuminuria, matched according to age, diagnosis and levels of haemoglobin, haematocrit and foetal haemoglobin did not receive enalapril and were followed up as the control group during the same period of study. Echocardiograms were performed before the study entry and after 36 months of follow-up. Results - At 36 months of follow-up, significant increases in left ventricular mass, left ventricular mass index, posterior left ventricular wall thickness in end-diastole, interventricular septal wall thickness in end-diastole, and aortic root diameter values were seen in untreated, but not in enalapril-treated patients. No major changes were seen in left ventricular systolic diameter, diastolic dimension and ejection fraction, and left atrial diameter, in both groups, along the observational period. Conclusion - The results of this study suggest that enalapril prevents cardiac remodelling in SCD patients. However, a large trial concerning the response to enalapril in patients with SCD should be carried out to further clarify this issue.pt
dc.relation.ispartofActa Cardiologicapt_BR
dc.relation.ispartofabbreviationActa Cardiol.pt_BR
dc.publisher.cityBrusselspt_BR
dc.publisher.countryBélgicapt_BR
dc.publisherActa Cardiologicapt_BR
dc.date.issued2008pt_BR
dc.date.monthofcirculationOCTpt_BR
dc.identifier.citationActa Cardiologica. Acta Cardiologica, v. 63, n. 5, n. 599, n. 602, 2008.pt_BR
dc.language.isoenpt_BR
dc.description.volume63pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage599pt_BR
dc.description.lastpage602pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0001-5385pt_BR
dc.identifier.wosidWOS:000260535200011pt_BR
dc.identifier.doi10.2143/AC.63.5.2033227pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2014-11-20T05:46:41Z
dc.date.available2015-11-26T16:07:15Z-
dc.date.accessioned2014-11-20T05:46:41Z
dc.date.accessioned2015-11-26T16:07:15Z-
dc.description.provenanceMade available in DSpace on 2014-11-20T05:46:41Z (GMT). No. of bitstreams: 1 WOS000260535200011.pdf: 285931 bytes, checksum: a485447c53448adbd6a4dc38d348541b (MD5) Previous issue date: 2008en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:07:15Z (GMT). No. of bitstreams: 2 WOS000260535200011.pdf: 285931 bytes, checksum: a485447c53448adbd6a4dc38d348541b (MD5) WOS000260535200011.pdf.txt: 19876 bytes, checksum: 8d72fc5120492e3fdb2c7328648e33e1 (MD5) Previous issue date: 2008en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64713pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/64713
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64713-
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