Enantioselective syntheses of (R)- and (S)-argentilactone and their cytotoxic activities against cancer cell lines

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Type:	Artigo de periódico
Title:	Enantioselective syntheses of (R)- and (S)-argentilactone and their cytotoxic activities against cancer cell lines
Author:	de Fatima, A Kohn, LK Antonio, MA de Carvalho, JE Pilli, RA
Abstract:	Concise total syntheses of (R)- and (S)-argentilactone have been developed via enantioselective catalytic allylation (ECA) and ring-closing metathesis pathways (four steps, 39% overall yield and 82-84% ee) from 2-octynal and their in vitro activity against cancer cells is described. (C) 2004 Elsevier Ltd. All rights reserved.
Subject:	argentilactone asymmetric synthesis cytotoxic activity cancer cell
Country:	Inglaterra
Editor:	Pergamon-elsevier Science Ltd
Citation:	Bioorganic & Medicinal Chemistry. Pergamon-elsevier Science Ltd, v. 12, n. 20, n. 5437, n. 5442, 2004.
Rights:	fechado
Identifier DOI:	10.1016/j.bmc.2004.07.044
Date Issue:	2004
Appears in Collections:	Unicamp - Artigos e Outros Documentos

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