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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEndothelin ETA receptor antagonism attenuates the presser effects of nicotine in ratspt_BR
dc.contributor.authorTanus-Santos, JEpt_BR
dc.contributor.authorSampaio, RCpt_BR
dc.contributor.authorHyslop, Spt_BR
dc.contributor.authorFranchini, KGpt_BR
dc.contributor.authorMoreno, Hpt_BR
unicamp.authorState Univ Campinas UNICAMP, Fac Med Sci, Dept Pharmacol, BR-13081970 Campinas, SP, Brazil State Univ Campinas, Fac Med Sci, Dept Clin Med, BR-13081970 Campinas, SP, Brazilpt_BR
dc.subjectblood pressurept_BR
dc.subjectendothelin receptor antagonistpt_BR
dc.subjectnicotinept_BR
dc.subject(rat)pt_BR
dc.subjectthromboxanept_BR
dc.subject.wosCigarette-smokingpt_BR
dc.subject.wosCardiovascular-diseasept_BR
dc.subject.wosBlood-pressurept_BR
dc.subject.wosConscious Ratspt_BR
dc.subject.wosThromboxane-a2pt_BR
dc.subject.wosProstacyclinpt_BR
dc.subject.wosMetabolitespt_BR
dc.subject.wosReleasept_BR
dc.subject.wosRabbitpt_BR
dc.subject.wosCellspt_BR
dc.description.abstractThe increased endotheIin-1 levels observed after smoking may result from nicotine-stimulated endothelin-1 production by endothelial cells. In this study, we investigated the effects of selective endothelin ETA receptors antagonist Cycle D-a-aspartyl-L-prolyl-D-isoleucyl-D-tryptophyl (JKC 301) and of endothelin ETB receptors antagonist N-cis-2,6-dimethylpiperidino-carbonyl-L-gamma-methyl-leucyl-D-L-methoxycarbonyl-tryptophanyl-norleucine (BQ 788) on the changes in mean arterial pressure, heart rate, and plasma thromboxane B-2 (the stable product of thromboxane A(2)) levels caused by increasing doses of nicotine (0.6, 2, 6, and 20 mu mol/kg) in anesthetised rats. Nicotine (0.6, 2, and 6 mu mol/kg) significantly increased the mean arterial pressure in control and BQ 788-pretreated rats, while only a nicotine dose of 2 mu mol/kg) increased the mean arterial pressure in JKC 301-pretreated animals. There were no differences in the nicotine-induced changes in heart rate or in the increases in thromboxane B-2 levels among the groups treated with saline, JKC 301 and BQ 788. These results demonstrate that whereas the antagonism of-endothelin ETA receptors attenuated the increase in blood pressure after nicotine injections, endothelin ETB receptor antagonism had no such effect. In addition, the antagonism of endothelin ETA or ETB receptors did not affect thromboxane A(2) production after nicotine administration. These findings suggest that endothelin-1 may have a role in the acute effects of nicotine. (C) 2000 Elsevier Science B.V. All rights reserved.pt
dc.relation.ispartofEuropean Journal Of Pharmacologypt_BR
dc.relation.ispartofabbreviationEur. J. Pharmacol.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryHolandapt_BR
dc.publisherElsevier Science Bvpt_BR
dc.date.issued2000pt_BR
dc.date.monthofcirculationMAY 12pt_BR
dc.identifier.citationEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 396, n. 1, n. 33, n. 37, 2000.pt_BR
dc.language.isoenpt_BR
dc.description.volume396pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage33pt_BR
dc.description.lastpage37pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0014-2999pt_BR
dc.identifier.wosidWOS:000087141100006pt_BR
dc.identifier.doi10.1016/S0014-2999(00)00194-1pt_BR
dc.date.available2014-12-02T16:30:33Z
dc.date.available2015-11-26T17:40:05Z-
dc.date.accessioned2014-12-02T16:30:33Z
dc.date.accessioned2015-11-26T17:40:05Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T17:40:05Z (GMT). No. of bitstreams: 2 WOS000087141100006.pdf: 119883 bytes, checksum: 88be939aed60b011dea5a733743d7c74 (MD5) WOS000087141100006.pdf.txt: 21539 bytes, checksum: 98a69594910cab0dce1a6b5e905a9ffb (MD5) Previous issue date: 2000en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64775pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/64775
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64775-
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