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Type: Artigo de periódico
Title: Free radical scavenging and antiproliferative properties of Biginelli adducts
Author: da Silva, DL
Reis, FS
Muniz, DR
Ruiz, ALTG
de Carvalho, JE
Sabino, AA
Modolo, LV
de Fatima, A
Abstract: A series of Biginelli adducts bearing different substituents at C-4 position were synthesized by using p-sulfonic acid calix[4] arene as a catalyst. The in vitro potential to scavenge reactive nitrogen/oxygen species (RNS and ROS) and the ability to inhibit cancer cells growth were then investigated. Four adducts were found to be potent scavengers of 2,2-diphenyl-1-picrylhydrazyl (RNS) and/or superoxide anion (ROS) radicals. The antiproliferative activity against cancer cells was disclosed for the first time for 16 monastrol analogs. The capacity of all compounds to inhibit cancer cells growth was dependent on the histological origin of cells, except for BA24, which was highly active against all cell lines. BA20 and BA33 were as potent as the reference drug doxorubicin against adriamycin-resistant ovarian and prostate cancer cells, respectively. These results highlight some monastrol analogs as lead compounds for the design of new free radical scavengers and anticancer agents. (C) 2012 Elsevier Ltd. All rights reserved.
Subject: Biginelli adducts
Free radical scavenging
Antiproliferative activity
Cancer cells
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Bioorganic & Medicinal Chemistry. Pergamon-elsevier Science Ltd, v. 20, n. 8, n. 2645, n. 2650, 2012.
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2012.02.036
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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