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Type: Artigo de periódico
Title: Presence of a Na+/H+ exchanger in acidocalcisomes of Leishmania donovani and their alkalization by anti-leishmanial drugs
Author: Vercesi, AE
Rodrigues, CO
Catisti, R
Docampo, R
Abstract: Acidocalcisomes are acidic vacuoles present in trypanosomatids that contain most of the cellular calcium. The data presented here demonstrate that Leishmania donovani acidocalcisomes possess a Na+/H+ exchanger. 3,5-Dibutyl-4-hydroxytoulene, in the concentration range of 0-20 mu M, inhibited the Na+/H+ exchanger, and strongly stimulated the activity of the vacuolar H+-ATPase responsible for vacuolar acidification. As occurs with Na+, the cationic anti-leishmanial drugs pentamidine, WR-6026, and chloroquine promoted a fast and extensive alkalization of the L, donovani acidocalcisomes. (C) 2000 Federation of European Biochemical Societies.
Subject: acidocalcisome
Na+/H+ exchanger
Leishmania donovani
Country: Holanda
Editor: Elsevier Science Bv
Citation: Febs Letters. Elsevier Science Bv, v. 473, n. 2, n. 203, n. 206, 2000.
Rights: fechado
Identifier DOI: 10.1016/S0014-5793(00)01531-3
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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