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Type: Artigo de periódico
Title: Prevalence of dyslipidemia in middle-aged adults with NOS3 gene polymorphism and low cardiorespiratory fitness
Author: Malagrino, PA
Sponton, CHG
Esposti, RD
Franco-Penteado, CF
Fernandes, RA
Bezerra, MAC
Albuquerque, DM
Rodovalho, CM
Bacci, M
Zanesco, A
Abstract: Objective: To evaluate the influence of the interaction between endothelial nitric oxide synthase gene (NOS3) polymorphisms at positions -786T>C, Glu298Asp and intron 4b/a, and cardiorespiratory fitness on plasma nitrite/nitrate levels, blood pressure, lipid profile, and prevalence of cardiometabolic disorders. Subjects and methods: Ninety-two volunteers were genotyped for NOS3 polymorphisms at positions (-786T>C and Glu298Asp) and (intron 4b/a) and divided according to the genotype: non-polymorphic (NP) and polymorphic (P). After that, they were subdivided according to the cardiorespiratory fitness associated with genotype: high (HNP and HP) and low (LNP and LP). Results: The subjects with polymorphism for the interactions at positions Glu298Asp + intron 4b/a, and Glu298Asp+-786T>C showed the highest values in total cholesterol, as well as dyslipidemia. Conclusion: Our findings show that NOS3 gene polymorphisms at positions -786T>C, Glu298Asp, and intron 4b/a exert negative effects on the lipid profile compared with those who do not carry polymorphisms. Arq Bras Endocrinol Metab. 2013;57(1):33-43
Subject: Polymorphism
cardiorespiratory fitness
Country: Brasil
Editor: Sbem-soc Brasil Endocrinologia & Metabologia
Citation: Arquivos Brasileiros De Endocrinologia E Metabologia. Sbem-soc Brasil Endocrinologia & Metabologia, v. 57, n. 1, n. 33, n. 43, 2013.
Rights: aberto
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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