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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleReticulocyte evaluation in alpha(+)-thalassemiapt_BR
dc.contributor.authorKrugner, Fpt_BR
dc.contributor.authorZaccariotto, TRpt_BR
dc.contributor.authorRosim, ETpt_BR
dc.contributor.authorCosta, FFpt_BR
dc.contributor.authorGrotto, HZWpt_BR
dc.contributor.authorSonati, MFpt_BR
unicamp.authorUniv Estadual Campinas, Sch Med Sci, Dept Clin Pathol, Sao Paulo, Brazil Univ Estadual Campinas, Sch Med Sci, Hematol & Hemotherapy Ctr, Sao Paulo, Brazilpt_BR
dc.subjectreticulocyte evaluationpt_BR
dc.subjectsoluble transferrin receptorpt_BR
dc.subjectserum erythropoietinpt_BR
dc.subjectBrazilian populationpt_BR
dc.subject.wosSoluble Transferrin Receptorpt_BR
dc.subject.wosIron Statuspt_BR
dc.description.abstractAlthough it is almost certain that alpha(+)-thalassemia protects against malaria, the mechanisms for that are still unknown. It has been suggested that an increased number of young circulating red blood cells in alpha(+)-thalassemic children, as a result of some degree of ineffective erythropoiesis, could be related to the high frequencies of the a+-thalassemic allele in malaria endemic areas. Reticulocyte evaluation in this condition, however, has been poorly performed so far. Our objective was to determine the reticulocyte number and maturation degree, in addition to the soluble transferrin receptor and serum erythropoietin levels, in alpha(+)-thalassemia heterozygotes, comparing them with normal alpha-genotype controls. One hundred twenty-one alpha(+)-thalassemia carriers (-alpha(3.7)/alpha alpha) and 249 controls (alpha alpha(alpha alpha), all of them with normal serum ferritin levels, were subclassified according to age (1-5, 6-10, 11-15, 16-20, and over 20 years old). Reticulocyte analyzes were carried out by flow cytometry and sTfR and s-Epo levels determined by immunonephelometry and chemiluminescence, respectively. The comparisons did not show any significant difference between thalassemics and controls regarding the reticulocyte parameters [percentages and absolute values, P = 0.2643 and 0.5421; high, medium, and low maturation degree, P = 0.2579, 0.2196, and 0.4192; RET maturity index (RMI), P = 0.2471, respectively], as well as the s-Epo levels (P = 0.5711). The sTfR concentrations were higher in the thalassemic group (P = 0.0001), but statistical significance was due only to the 1-5 and over 20 subgroups (P = 0.0082 and 0.0436, respectively). The results found here are compatible with a compensated erythropoiesis and do not confirm the hypothesis mentioned
dc.relation.ispartofAmerican Journal Of Hematologypt_BR
dc.relation.ispartofabbreviationAm. J. Hematol.pt_BR
dc.identifier.citationAmerican Journal Of Hematology. Wiley-liss, v. 81, n. 1, n. 68, n. 70, 2006.pt_BR
dc.sourceWeb of Sciencept_BR
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