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Type: Artigo de periódico
Title: Which comes first: Renal inflammation or oxidative stress in spontaneously hypertensive rats?
Author: Biswas, SK
De Faria, JBL
Abstract: The present study was undertaken to identify whether inflammation or oxidative stress is the primary abnormality in the kidney in spontaneously hypertensive rats (SHR). Renal inflammation and oxidative stress were evaluated in 2- and 3-week-old prehypertensive SHR and age-matched genetically normotensive control Wistar-Kyoto (WKY) rats. Blood pressure was similar in WKY and SHR rats at 2 and 3 weeks, of age. Renal inflammation (macrophage and nuclear factor-kappa B) was elevated in SHR at 3 weeks, but not at 2 weeks, of age compared with age-matched WKY rats. Renal oxidative stress (nitrotyrosine, 8-hydroxy-2'-deoxyguanosine and p47phox) was also clearly elevated in 3-week-old SHR compared with age-matched WKY rats. Additionally, NADPH oxidase subunit p47phox was found elevated in 2-week-old SHR compared to age-matched WKY rats. Moreover, antioxidant (N-acetyl-L-cysteine and Tempol) treatment reduced renal inflammation in prehypertensive SHR. We therefore conclude that the oxidative stress appears before inflammation as a primary abnormality in the kidney in prehypertensive SHR.
Subject: oxidative stress
NF-kappa Bp65
Country: Inglaterra
Editor: Taylor & Francis Ltd
Citation: Free Radical Research. Taylor & Francis Ltd, v. 41, n. 2, n. 216, n. 224, 2007.
Rights: fechado
Identifier DOI: 10.1080/10715760601059672
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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