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Type: Artigo de periódico
Title: Unsaturated Fatty Acids Revert Diet-Induced Hypothalamic Inflammation in Obesity
Author: Cintra, DE
Ropelle, ER
Moraes, JC
Pauli, JR
Morari, J
de Souza, CT
Grimaldi, R
Stahl, M
Carvalheira, JB
Saad, MJ
Velloso, LA
Abstract: Background: In experimental models, hypothalamic inflammation is an early and determining factor in the installation and progression of obesity. Pharmacological and gene-based approaches have proven efficient in restraining inflammation and correcting the obese phenotypes. However, the role of nutrients in the modulation of hypothalamic inflammation is unknown. Methodology/Principal Findings: Here we show that, in a mouse model of diet-induced obesity, partial substitution of the fatty acid component of the diet by flax seed oil (rich in C18:3) or olive oil (rich in C18:1) corrects hypothalamic inflammation, hypothalamic and whole body insulin resistance, and body adiposity. In addition, upon icv injection in obese rats, both omega 3 and omega 9 pure fatty acids reduce spontaneous food intake and body mass gain. These effects are accompanied by the reversal of functional and molecular hypothalamic resistance to leptin/insulin and increased POMC and CART expressions. In addition, both, omega 3 and omega 9 fatty acids inhibit the AMPK/ACC pathway and increase CPT1 and SCD1 expression in the hypothalamus. Finally, acute hypothalamic injection of omega 3 and omega 9 fatty acids activate signal transduction through the recently identified GPR120 unsaturated fatty acid receptor. Conclusions/Significance: Unsaturated fatty acids can act either as nutrients or directly in the hypothalamus, reverting diet-induced inflammation and reducing body adiposity. These data show that, in addition to pharmacological and genetic approaches, nutrients can also be attractive candidates for controlling hypothalamic inflammation in obesity.
Country: EUA
Editor: Public Library Science
Citation: Plos One. Public Library Science, v. 7, n. 1, 2012.
Rights: aberto
Identifier DOI: 10.1371/journal.pone.0030571
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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