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Type: Artigo de periódico
Title: The Genome of Anopheles darlingi, the main neotropical malaria vector
Author: Marinotti, O
Cerqueira, GC
de Almeida, LGP
Ferro, MIT
Loreto, ELD
Zaha, A
Teixeira, SMR
Wespiser, AR
Silva, AAE
Schlindwein, AD
Pacheco, ACL
da Silva, ALD
Graveley, BR
Walenz, BP
Lima, BD
Ribeiro, CAG
Nunes-Silva, CG
de Carvalho, CR
Soares, CMD
de Menezes, CBA
Matiolli, C
Caffrey, D
Araujo, DAM
de Oliveira, DM
Golenbock, D
Grisard, EC
Fantinatti-Garboggini, F
de Carvalho, FM
Barcellos, FG
Prosdocimi, F
May, G
de Azevedo, GM
Guimaraes, GM
Goldman, GH
Padilha, IQM
Batista, JD
Ferro, JA
Ribeiro, JMC
Fietto, JLR
Dabbas, KM
Cerdeira, L
Agnez-Lima, LF
Brocchi, M
de Carvalho, MO
Teixeira, MD
Maia, MDD
Goldman, MHS
Cruz Schneider, MPC
Felipe, MSS
Hungria, M
Nicolas, MF
Pereira, M
Montes, MA
Cantao, ME
Vincentz, M
Rafael, MS
Silverman, N
Stoco, PH
Souza, RC
Vicentini, R
Gazzinelli, RT
Neves, RD
Silva, R
Astolfi, S
Maciel, TEF
Urmenyi, TP
Tadei, WP
Camargo, EP
de Vasconcelos, ATR
Abstract: Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors similar to 100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector-human and vector-parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at
Country: Inglaterra
Editor: Oxford Univ Press
Citation: Nucleic Acids Research. Oxford Univ Press, v. 41, n. 15, n. 7387, n. 7400, 2013.
Rights: aberto
Identifier DOI: 10.1093/nar/gkt484
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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