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Type: Artigo de periódico
Title: The genome sequence of the plant pathogen Xylella fastidiosa
Author: Simpson, AJG
Reinach, FC
Arruda, P
Abreu, FA
Acencio, M
Alvarenga, R
Alves, LMC
Araya, JE
Baia, GS
Baptista, CS
Barros, MH
Bonaccorsi, ED
Bordin, S
Bove, JM
Briones, MRS
Bueno, MRP
Camargo, AA
Camargo, LEA
Carraro, DM
Carrer, H
Colauto, NB
Colombo, C
Costa, FF
Costa, MCR
Costa-Neto, CM
Coutinho, LL
Cristofani, M
Dias-Neto, E
Docena, C
El-Dorry, H
Facincani, AP
Ferreira, AJS
Ferreira, VCA
Ferro, JA
Fraga, JS
Franca, SC
Franco, MC
Frohme, M
Furlan, LR
Garnier, M
Goldman, GH
Goldman, MHS
Gomes, SL
Gruber, A
Ho, PL
Hoheisel, JD
Junqueira, ML
Kemper, EL
Kitajima, JP
Krieger, JE
Kuramae, EE
Laigret, F
Lambais, MR
Leite, LCC
Lemos, EGM
Lemos, MVF
Lopes, SA
Lopes, CR
Machado, JA
Machado, MA
Madeira, AMBN
Madeira, HMF
Marino, CL
Marques, MV
Martins, EAL
Martins, EMF
Matsukuma, AY
Menck, CFM
Miracca, EC
Miyaki, CY
Monteiro-Vitorello, CB
Moon, DH
Nagai, MA
Nascimento, ALTO
Netto, LES
Nhani, A
Nobrega, FG
Nunes, LR
Oliveira, MA
de Oliveira, MC
de Oliveira, RC
Palmieri, DA
Paris, A
Peixoto, BR
Pereira, GAG
Pereira, HA
Pesquero, JB
Quaggio, RB
Roberto, PG
Rodrigues, V
Rosa, AJD
de Rosa, VE
de Sa, RG
Santelli, RV
Sawasaki, HE
da Silva, ACR
da Silva, AM
da Silva, FR
Silva, WA
da Silveira, JF
Silvestri, MLZ
Siqueira, WJ
de Souza, AA
de Souza, AP
Terenzi, MF
Truffi, D
Tsai, SM
Tsuhako, MH
Vallada, H
Van Sluys, MA
Verjovski-Almeida, S
Vettore, AL
Zago, MA
Zatz, M
Meidanis, J
Setubal, JC
Abstract: Xylella fastidiosa is a fastidious, xylem-limited bacterium that causes a range of economically important plant diseases. Here we report the complete genome sequence of X. fastidiosa clone 9a5c, which causes citrus variegated chlorosis-a serious disease of orange trees. The genome comprises a 52.7% GC-rich 2,679,305-base-pair (bp) circular chromosome and two plasmids of 51,158 bp and 1,285 bp. We can assign putative functions to 47% of the 2,904 predicted coding regions. Efficient metabolic functions are predicted, with sugars as the principal energy and carbon source, supporting existence in the nutrient-poor xylem sap. The mechanisms associated with pathogenicity and virulence involve toxins, antibiotics and ion sequestration systems, as well as bacterium-bacterium and bacterium-host interactions mediated by a range of proteins. Orthologues of some of these proteins have only been identified in animal and human pathogens; their presence in X. fastidiosa indicates that the molecular basis for bacterial pathogenicity is both conserved and independent of host. At least 83 genes are bacteriophage-derived and include virulence-associated genes from other bacteria, providing direct evidence of phage-mediated horizontal gene transfer.
Country: Inglaterra
Editor: Macmillan Publishers Ltd
Citation: Nature. Macmillan Publishers Ltd, v. 406, n. 6792, n. 151, n. 157, 2000.
Rights: fechado
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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